PLK4-IN-7
PLK4-IN-7 is a selective and orally active PLK4 inhibitor with an IC50 value of 7.9 nM. PLK4-IN-7 exhibits potent antitumor activity and favorable metabolic stability. PLK4-IN-7 can be used for the research of tumors such as neuroblastoma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C20H19F6N7O2
- Molecular Weight:503.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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PLK4 7.9 nM (IC50) |
PLK4-IN-7 (Compound 25) (5 days) can inhibit the viability of CHP-134 neuroblastoma cells, with an EC50 value of 88 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CHP-134 neuroblastoma tumor-bearing mouse xenograft model[1]
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Dosage:30 mg/kg, 100 mg/kg
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Administration:p.o., twice daily for 16 days
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Result:Was well-tolerated with no significant body weight loss observed during the treatment period, and the final tumor growth inhibition rates were 115% (30 mg/kg group) and 117% (100 mg/kg group), respectively.
Chemical Information
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Molecular Weight 503.40
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Formel C20H19F6N7O2
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SMILES
O=C(NC1=CNN=C1C2=CC3=C(C=N2)C=NN3CC(F)(F)F)N4C5(C[C@@](C(F)(F)F)(CC4)O)CC5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PLK4-IN-7 Related Classifications
HY-180111 Related Classifications
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