CD367/CLEC4A
CD367, or DCIR (CLEC4A), is an inhibitory C-type lectin receptor of the DC-SIGN subfamily expressed on dendritic cells and macrophages. Its hallmark is a cytoplasmic ITIM that recruits phosphatases to restrain signaling from activating receptors, positioning DCIR as a negative regulator of antigen-presenting-cell function. The extracellular lectin domain binds high-mannose glycans and has been shown to capture HIV-1 gp120, promoting viral attachment and trans-infection of T cells; it also interacts with vimentin exposed on certain cells. Because of these properties, recombinant CD367/CLEC4A is valuable for HIV-entry studies, glycan-binding analysis, and research on inhibitory lectin checkpoints in innate immunity.
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CD367/CLEC4A Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
