IgE
IgE circulates at the lowest concentration of all immunoglobulin classes, yet it is the central driver of allergic disease and antiparasite immunity. Through its Fc region IgE binds the high-affinity Fc epsilon RI on mast cells and basophils with exceptional stability, so receptor occupancy persists for weeks and sensitizes these cells to specific allergens. Antigen-mediated cross-linking of bound IgE triggers degranulation, releasing histamine, leukotrienes, and cytokines that produce immediate hypersensitivity and, systemically, anaphylaxis. IgE also supports defense against helminths by activating eosinophils and mast cells. The anti-IgE antibody omalizumab, which blocks Fc epsilon RI binding, established IgE as a validated drug target in asthma and chronic urticaria.
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IgE Recombinant Proteins (8)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
