IgG1
IgG1 is the most abundant human IgG subclass, accounting for the majority of circulating IgG and mounting strong responses to protein antigens from viruses and bacteria. Its Fc region combines high-affinity engagement of activating Fc gamma receptors, including CD64 and CD16a, with efficient C1q binding, making IgG1 the strongest complement-fixing and ADCC-mediating subclass. These properties explain why most approved therapeutic monoclonal antibodies, from rituximab to trastuzumab, use an IgG1 Fc, often with glycoengineering or Fc mutation to tune effector function. IgG1 also crosses the placenta efficiently and displays the long serum half-life conferred by FcRn recycling.
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IgG1 Recombinant Proteins (12)
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- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
