IgG3
IgG3 is the most potent human IgG subclass in effector terms: its extended, flexible hinge exposes the Fc region such that IgG3 fixes complement C1q more efficiently than any other subclass and binds activating Fc gamma receptors with high avidity, producing strong ADCC and inflammatory responses. These properties make IgG3 prominent in responses to viral and bacterial protein antigens and in anti-erythrocyte alloimmunization. The same subclass carries the shortest serum half-life among human IgG proteins, roughly a week, because its Fc region binds the recycling receptor FcRn less effectively. IgG3 Fc variants are studied when maximal complement recruitment is therapeutically desirable.
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IgG3 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
