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Art. -Nr.: HY-P5153

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ProTx-III

(Synonyms: μ-TRTX-Tp1a)

ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Na_v1.7, with an IC₅₀ of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia.

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CAS. Nr.: 1808297-63-3
Formel: C₁₆₂H₂₄₆N₅₂O₄₃S₆
Molecular Weight:3802.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ProTx-III Chemical Structure

CAS. Nr.: 1808297-63-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Na_v1.7

2.1 nM (IC₅₀)

Alle Sodium Channel Isoform-spezifische Produkte anzeigen :

In Vitro

ProTx-III in native, recombinant and synthetic C-terminal acid and amide forms inhibit hNaV1.7 with IC₅₀s of 2.1, 9.5, 11.5 and 2.5 nM, respectively^[1].
. ProTx-III inhibits hNav1.7 without significantly altering the voltage dependence of activation or inactivation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ProTx-III (0.01-1 μM; intraplantar injection) can proves to be analgesic by reversing spontaneous pain induces in mice by intraplantar injection in OD1 in mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

OD1-induced mouse model of pain(300Nm; intraplantar injection)^[1]
Dosage:

100 nM, 300 nM, 1μM
Administration:

intraplantar injection
Result:

Showed at 1 μM (40 pmoles in a 40 μl injection) and 300 nM (12 pmoles in a 40 μl injection) significantly reduced spontaneous pain behaviour in a concentration dependent manner and this reduction in pain behaviour persisted for 25 min after injection of the highest concentration.

Chemical Information

CAS. Nr. 1808297-63-3
Molecular Weight 3802.40
Formel C₁₆₂H₂₄₆N₅₂O₄₃S₆
Synonyms

μ-TRTX-Tp1a
Sequence

Asp-Cys-Leu-Lys-Phe-Gly-Trp-Lys-Cys-Asn-Pro-Arg-Asn-Asp-Lys-Cys-Cys-Ser-Gly-Leu-Lys-Cys-Gly-Ser-Asn-His-Asn-Trp-Cys-Lys-Leu-His-Ile-NH2 (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
Sequence Shortening

DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI-NH2 (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cardoso FC, et al. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Mol Pharmacol. 2015 Aug;88(2):291-303. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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ProTx-III

Alle Sodium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ProTx-III Related Classifications

HY-P5153 Related Classifications