PYD-106
Based on 1 Customer Validation
PYD-106 is a stereoselective pyrrolidinone (PYD) positive allosteric modulator for GluN2C-containing NMDA receptors. PYD-106 increases opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only has modest effects on glutamate and glycine EC50. PYD-106 selectively enhances the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors.
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- Reinheit: 98.13%
- CAS. Nr.: 1560894-05-4
- Formel: C25H24N2O5
- Molecular Weight:432.47
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Biologische Aktivität
Chemical Information
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CAS. Nr. 1560894-05-4
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Appearance Solid
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Molecular Weight 432.47
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Formel C25H24N2O5
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Color Off-white to light yellow
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SMILES
O=C(OC)C1=CC=C(C(C(C(C)=O)=C2O)N(CCC3=C(C)NC4=C3C=CC=C4)C2=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (289.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3123 mL | 11.5615 mL | 23.1230 mL | 57.8075 mL |
| 5 mM | 0.4625 mL | 2.3123 mL | 4.6246 mL | 11.5615 mL | |
| 10 mM | 0.2312 mL | 1.1561 mL | 2.3123 mL | 5.7807 mL | |
| 15 mM | 0.1542 mL | 0.7708 mL | 1.5415 mL | 3.8538 mL | |
| 20 mM | 0.1156 mL | 0.5781 mL | 1.1561 mL | 2.8904 mL | |
| 25 mM | 0.0925 mL | 0.4625 mL | 0.9249 mL | 2.3123 mL | |
| 30 mM | 0.0771 mL | 0.3854 mL | 0.7708 mL | 1.9269 mL | |
| 40 mM | 0.0578 mL | 0.2890 mL | 0.5781 mL | 1.4452 mL | |
| 50 mM | 0.0462 mL | 0.2312 mL | 0.4625 mL | 1.1561 mL | |
| 60 mM | 0.0385 mL | 0.1927 mL | 0.3854 mL | 0.9635 mL | |
| 80 mM | 0.0289 mL | 0.1445 mL | 0.2890 mL | 0.7226 mL | |
| 100 mM | 0.0231 mL | 0.1156 mL | 0.2312 mL | 0.5781 mL |
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