Quinocarcin
Quinocarcin (DC-52) is a potent antitumor antibiotic. Quinocarcin inhibits Bacillus subtilis DNA, RNA and protein syntheses.
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- CAS. Nr.: 84573-33-1
- Formel: C18H22N2O4
- Molecular Weight:330.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vitro
Quinocarcin (100 µg/mM; 0-20 min) inhibits Bacillus subtilis DNA, RNA and protein syntheses[1].
Quinocarcin (0.1, 1, 10 mM) interactes with PM2 DNA in a dose-dependent manner[1].
Quinocarcin (0-100 µM) shows cell cytotoxicity with LC50 values of >100, 3.18, 3.83, 0.49, 84.85, 43.27 µM for LOX-IMVI; SK-MEL-5, UACC-62, UACC-257, MALME-3M cells, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LOX-IMVI; SK-MEL-5, UACC-62, UACC-257, MALME-3M cells
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Concentration:0-100 µM
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Incubation Time:
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Result:Showed cell cycotoxicity with 50% cytotoxicity (LC50) values of >100, 3.18, 3.83, 0.49, 84.85, 43.27 µM for LOX-IMVI; SK-MEL-5, UACC-62, UACC-257, MALME-3M cells, respectively.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (SK-MEL-2 tumors) [3]
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Dosage:40 mg/kg
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Administration:I.p.; on days 14, 21, and 28
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Result:Inhibited tumor growth by 89%.
Chemical Information
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CAS. Nr. 84573-33-1
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Molecular Weight 330.38
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Formel C18H22N2O4
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SMILES
O=C(O)[C@@H]1[C@]2([C@]([H])(N3[C@@]4(CO[C@]3([C@@]([H])(C1)N2C)[H])[H])CC5=C4C(OC)=CC=C5)[H]
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Synonyms
Quinocarmycin; DC-52; KW2152 free base
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Tomita F, et al. Quinocarcin, a novel antitumor antibiotic. 3. Mode of action. J Antibiot (Tokyo). 1984 Oct;37(10):1268-72. [Content Brief]
[2]. Kahsai AW, et al. Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. Chem Biol. 2006 Sep;13(9):973-83. [Content Brief]
[3]. Plowman J, et al. Efficacy of the quinocarmycins KW2152 and DX-52-1 against human melanoma lines growing in culture kand in mice. Cancer Res. 1995 Feb 15;55(4):862-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Quinocarcin Related Classifications
HY-129292 Related Classifications
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