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Art. -Nr.: HY-14974

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R 1487

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

R 1487 is an orally active and highly selective p38α mitogen-activated protein kinase inhibitor. R 1487 can be used in the study of rheumatoid arthritis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 449811-92-1
Formel: C₁₉H₁₈F₂N₄O₃
Molecular Weight:388.37

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

R 1487 Chemical Structure

CAS. Nr.: 449811-92-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Cellular Effect
Chemical Information
Publications (1)
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Biologische Aktivität

Beschreibung

R 1487 is an orally active and highly selective p38α mitogen-activated protein kinase inhibitor. R 1487 can be used in the study of rheumatoid arthritis^[1].

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	IC₅₀	0.047 μM Compound: 2a, R1487	Inhibition of LPS-induced TNFalpha production in human THP1 cells after 2 hrs by ELISA Inhibition of LPS-induced TNFalpha production in human THP1 cells after 2 hrs by ELISA	[PMID: 21375264]

Chemical Information

CAS. Nr. 449811-92-1
Molecular Weight 388.37
Formel C₁₉H₁₈F₂N₄O₃
SMILES

O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC4CCOCC4)N=C3N1C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Dis Model Mech

A Drosophila chemical screen reveals targeting MEK and DGKa mitigates Ras-driven polarity-impaired tumour growth. [Abstract]

2023 Mar 1;16(3):dmm049769. PMID: 36861754

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Goldstein DM, et al. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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R 1487

1 Cited Publications

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Publications (1)
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R 1487

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) R 1487

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

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Chemical Information

Publications (1)

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R 1487

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) R 1487

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

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R 1487 Related Classifications

HY-14974 Related Classifications