Rasburicase
Based on 1 publication(s) in Google Scholar
Rasburicase is a recombinant form of urate oxidase that works by catalyzing the oxidation of uric acid to allantoin, which has a higher solubility. Rasburicase specifically degrades uric acid, rapidly lowers blood uric acid levels, and improves inflammation and kidney damage caused by uric acid crystal deposition. Rasburicase can effectively lower uric acid and prevent uric acid nephropathy, and is used in the study of severe hyperuricemia associated with tumor lysis syndrome (TLS) and refractory gout.
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- Reinheit: 95%
- CAS. Nr.: 134774-45-1
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Publications Citing Use of MedChemExpress (MCE) Rasburicase
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Biologische Aktivität
Rasburicase (100 μg; intravenous injection; 3 times; days -3, 0, +3) inhibits anti-rasburicase antibody production in mice, reduces the number of splenic antigen-specific B cells and T cells, and upregulates the proportion of regulatory T cells (Treg)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c Nude Mouse Tumor Lysis Syndrome (TLS) Model (male, 18-22 g, 6-8 weeks old): TLS induced by chemotherapy[1]
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Dosage:0.2 mg/kg
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Administration:Intravenous injection, once daily for 5-7 days
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Result:Significantly reduced serum uric acid levels by 86%.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 134774-45-1
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Appearance Lyophilized Powder
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Color White to off-white
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SMILES
[Rasburicase]
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Clin Invest
GLUT9b- and ABCG2-mediated collecting duct urate transport uncover a vasopressin-independent mechanism of renal water reabsorption. [Abstract]2026 Jun 16:e197021. PMID: 42298327
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Cammalleri L, et al. Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout. Int J Med Sci. 2007 Mar 2;4(2):83-93. [Content Brief]
[2]. Xu H, et al. High-Dose IV Administration of Rasburicase Suppresses Anti-rasburicase Antibodies, Depletes Rasburicase-Specific Lymphocytes, and Upregulates Treg Cells. AAPS J. 2020 May 27;22(4):80. [Content Brief]
[3]. Kono H, et al. Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest. 2010 Jun;120(6):1939-49. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Rasburicase Related Classifications
HY-108844 Related Classifications
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