RB-042
RB-042 is a SK1 and SK2 inhibitor with IC50 values of 5.3 μM and 5.0 μM, respectively. RB-042 is applicable to the research of inflammatory diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1491909-40-0
- Formel: C25H43NO
- Molecular Weight:373.63
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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SphK1 5.3 μM (IC50) |
SphK2 5.0 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
5.3 μM
Compound: RB-042
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Inhibition of recombinant sphingosine kinase 1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins in presence of [gamma32P]-ATP
Inhibition of recombinant sphingosine kinase 1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins in presence of [gamma32P]-ATP
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[PMID: 24164513] |
RB-042 is an equipotent inhibitor of sphingosine kinase 1 and sphingosine kinase 2, with an IC50 value of 5.3 μM against SK1 and 5.0 μM against SK2[1].
RB-042 binds to the catalytic site of sphingosine kinase 1 via polar interactions with residues D178, D81, and L268[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1491909-40-0
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Molecular Weight 373.63
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Formel C25H43NO
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SMILES
C(CC1=CC=C(CCCCCCCCCCCC)C=C1)N2[C@@H](CO)CCC2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Baek DJ, et al. Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. J Med Chem. 2013;56(22):9310-9327. [Content Brief]
[2]. Shrestha J, et al. Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation. Molecules. 2018;23(11):2750. Published 2018 Oct 24. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RB-042 Related Classifications
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