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Art. -Nr.: HY-114041

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Resolvin E1

(Synonyms: RvE1)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production.

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Reinheit: 98.1%
CAS. Nr.: 552830-51-0
Formel: C₂₀H₃₀O₅
Molecular Weight:350.45

Speicherung:

Solution, -20°C, 2 years

Resolvin E1 Chemical Structure

CAS. Nr.: 552830-51-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Resolvin E1 (0.1-100 nM) gives concentration-dependent inhibition of TNF-α–induced NF-κB activation with an EC₅₀ of ～1.0 nM in ChemR23-transfected cells. Resolvin E1 (100 nM) increases phosphorylation of extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase both in peripheral blood monocytes and HEK-ChemR23 cells^[2]. Resolvin E1 specifically interacts with the LTB₄ receptor BLT1 on neutrophils and ChemR23 on monocytes to regulate leukocytes during inflammation. Resolvin E1 also stimulates the uptake and clearance of local cytokine^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Resolvin E1 (1.0 μg per mouse; 50 μg/kg; i.p.; on days -8, -1, and 0) protects mice from TNBS (2,4,6-trinitrobenzene sulfonic acid) colitis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6- to 8-week-old female BALB/c mice (TNBS colitis model)^[1]
Dosage:

1.0 μg per mouse; 50 μg/kg
Administration:

i.p.; on days -8, -1, and 0 before the induction of colitis
Result:

Reduced overall mortality, which was 25% and 62.5% at 1.0 μg per mouse and 50 μg/kg, respectively.

Chemical Information

CAS. Nr. 552830-51-0
Appearance Liquid
Molecular Weight 350.45
Formel C₂₀H₃₀O₅
Color Colorless to light yellow
SMILES

CC[C@@H](O)/C=C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
Synonyms

RvE1
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Solution, -20°C, 2 years

Publications (2)

All Histological Imaging/StainingWBIFELISA

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Journal Impact Factor

Exp Neurol

RvE1/ChemR23 facilitates hematoma clearance and promotes M2 polarization of macrophages/microglia in intracerebral hemorrhage. [Abstract]

2025 Jan 30:115173. PMID: 39892453
Immunol Invest

Resolvin E1 and Inhibition of BLT2 Signaling Attenuate the Inflammatory Response and Improve One-Lung Ventilation-Induced Lung Injury. [Abstract]

2024 Sep 4:1-15. PMID: 39230105

Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]

Pathological alterations in lung tissues analyzed via H&E staining with Resolvin E1 (RvE1) treatment.

Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]

Expression levels of apoptotic markers Bax, bcl-2, and caspase-3 were evaluated through Western blot analysis with Resolvin E1 (RvE1) treatment.

Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]

Apoptosis in lung tissues quantified via TUNEL staining with Resolvin E1 (RvE1) treatment.

Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]

Quantification of inflammatory cytokines IL-8, tnf-α, IL-1β, GM-CSF (CSF2, colony stimulating factor 2), KC (CXCL1, chemokine ligand 1), MCP-1 (CCL2, Monocyte Chemotactic and activating factor), MIP-2 (CXCL2, chemokine ligand 2), and IL-6, as determined by ELISA with Resolvin E1 (RvE1) treatment.

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Arita M, et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7671-6. [Content Brief]

[2]. Schwab JM, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007 Jun 14;447(7146):869-74. [Content Brief]

[3]. Hasturk H, et al. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissuehomeostasis in vivo. J Immunol. 2007 Nov 15;179(10):7021-9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Resolvin E1

2 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Reinheit & Dokumentation
Verweise

1/16
1/16

Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]

Customer Validation
Pathological alterations in lung tissues analyzed via H&E staining with Resolvin E1 (RvE1) treatment.
1/16

Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]

Customer Validation
Expression levels of apoptotic markers Bax, bcl-2, and caspase-3 were evaluated through Western blot analysis with Resolvin E1 (RvE1) treatment.
1/16

Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]

Customer Validation
Apoptosis in lung tissues quantified via TUNEL staining with Resolvin E1 (RvE1) treatment.
1/16

Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]

Customer Validation
Quantification of inflammatory cytokines IL-8, tnf-α, IL-1β, GM-CSF (CSF2, colony stimulating factor 2), KC (CXCL1, chemokine ligand 1), MCP-1 (CCL2, Monocyte Chemotactic and activating factor), MIP-2 (CXCL2, chemokine ligand 2), and IL-6, as determined by ELISA with Resolvin E1 (RvE1) treatment.

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Resolvin E1

Publications Citing Use of MedChemExpress (MCE) Resolvin E1

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Resolvin E1 Related Classifications

HY-114041 Related Classifications