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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
246 Results for "
Retinal
" in MedChemExpress (MCE) Product Catalog:
Products (246)
246 Results for "Retinal" in MCE Product Catalog:
16
Category:
Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology
Target:
9
9 Cited Publications
Art. -Nr.: HY-D0799
CAS. Nr.: 191671-46-2
Target:
Forschungsgebiete:
Sulfo-NHS-LC-Biotin sodium is an amine-reactive ester derivative of biotin and cannot pass the intact blood-retinal barrier. It can be used to assess vascular permeability of the brain and retinal vasculature.
7
Target:
Forschungsgebiete:
Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .
7
Target:
Forschungsgebiete:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis .
6
Category:
Human Gut Microbiota Metabolites Natural Products Microorganisms Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields
Target:
6
Target:
5
5 Cited Publications
Target:
Forschungsgebiete:
CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS) .
5
5 Cited Publications
Art. -Nr.: HY-10968A
CAS. Nr.: 1783987-80-3
Target:
Forschungsgebiete:
CYM5442 hydrochloride is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 hydrochloride is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 hydrochloride activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 hydrochloride can easily penetrate the central nervous system (CNS) .
4
Target:
3
3 Cited Publications
Art. -Nr.: HY-W004500
CAS. Nr.: 116-31-4
Category:
Human Gut Microbiota Metabolites Microorganisms Terpenoids Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields
Target:
3
3 Cited Publications
Synonyms: NMDAR/TRPM4-IN-2
Target:
Forschungsgebiete:
Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss .
3
3 Cited Publications
Synonyms: NMDAR/TRPM4-IN-2 free base
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Forschungsgebiete:
Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss .
2
2 Cited Publications
Synonyms: A2E TFA; N-retinylidene-N-retinylethanolamine TFA
Forschungsgebiete:
Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases .
2
2
2 Cited Publications
Art. -Nr.: HY-W040045
CAS. Nr.: 18466-51-8
Synonyms: Pelargonidin-3-O-glucoside chloride
2
2 Cited Publications
Synonyms: ONO-2506; (R)-2-Propyloctanoic acid
Forschungsgebiete:
Arundic Acid is an orally effective astrocyte function modulator and neuroprotective agent. Arundic Acid increases the expression and function of the astrocytic glutamate transporter EAAT1 by activating the ERK, Akt and NF-κB pathways. Arundic Acid attenuates retinal ganglion cell death in a normal-tension glaucoma model. Arundic Acid exerts neuroprotective effects in a mouse model of Parkinson's disease. Arundic Acid is a S100β protein synthesis inhibitor that prevents neurological deficits and brain tissue damage after intracerebral hemorrhage in rats. Arundic Acid downregulates neuroinflammation and astrocytic dysfunction after status epilepticus in immature rats. Arundic Acid is applicable to research related to Parkinson's disease, cerebral ischemia, glaucoma, intracerebral hemorrhage and epilepsy .
1
1 Cited Publications
Synonyms: Levisoprenaline hydrochloride; Proternol L hydrochloride
Target:
Forschungsgebiete:
(-)-Isoproterenol (Levisoprenalinel) hydrochloride is the R-isomer of Isoproterenol. (-)-Isoproterenol hydrochloride can reduce the cleavage of caspase 3 and TNFα levels in retinal endothelial cells (REC). (-)-Isoproterenol hydrochloride can be used for the study of diabetic retinopathy .
1
1 Cited Publications
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Forschungsgebiete:
HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration .
1
1 Cited Publications
Art. -Nr.: HY-N0606
CAS. Nr.: 105558-26-7
Category:
Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae Extract
Target:
1
1 Cited Publications
Art. -Nr.: HY-P1663A
Target:
Forschungsgebiete:
ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis . ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
