SID 24785302
SID 24785302 is a hexokinase inhibitor with antiparasitic activity. SID 24785302 exhibits activity against T. brucei and Leishmania. SID 24785302 can be used for the research of mitochondrial DNA disorders and parasitic infection.
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- CAS. Nr.: 378197-09-2
- Formel: C14H12N2O3S2
- Molecular Weight:320.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
SID 24785302 (10 μM; 2 h) potently and selectively inhibits bacterially expressed Trypanosoma brucei hexokinase 1 with an IC50 of 4.2 μM, while causing minimal inhibition of human glucokinase at 10 μM[3].
SID 24785302 (3 days) potently inhibits the growth of Trypanosoma brucei bloodstream form parasites with an EC50 of 0.042 μM[3].
SID 24785302 (10 μM; 2 days) moderately inhibits the growth of Trypanosoma brucei procyclic form parasites, causing 47% inhibition at 10 μM[3].
SID 24785302 (44 h) inhibits the growth of Leishmania major promastigotes with an EC50 of 1.9 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 378197-09-2
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Molecular Weight 320.39
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Formel C14H12N2O3S2
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SMILES
O=C(CC1=CSC(N2SC3=C(C2=O)C=CC=C3)=N1)OCC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Antonella SPINAZZOLA, et al. Compounds for treating mitochondrial dna disorders. WO2023089313A1.
[2]. Heneberg P. Redox Regulation of Hexokinases. Antioxid Redox Signal. 2019 Jan 20;30(3):415-442. [Content Brief]
[3]. Sharlow ER, et al. A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. PLoS Negl Trop Dis. 2010;4(4):e659. Published 2010 Apr 13. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SID 24785302 Related Classifications
HY-169728 Related Classifications
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- SID 24785302
- 378197-09-2
- SID24785302
- SID-24785302
- Hexokinase
- Parasite
- mitochondrial DNA disorders
- hexokinase inhibitor
- T. brucei blood stage parasites
- Trypanosoma brucei procyclic form (29-13)
- CYP2D6
- Trypanosoma brucei bloodstream form (90-13)
- Leishmania promastigotes
- Trypanosoma brucei hexokinase 1
- human african trypanosomiasis
- Leishmania major promastigotes
- Inhibitor
- inhibitor
- inhibit