country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-107191

Copy Link Print Information

Sildenafil Mesylate

Name: Sildenafil Mesylate
Brand: MedChemExpress
SKU: HY-107191
Availability: PreOrder

18 Cited Publications

Kundenbewertung

Based on 18 publication(s) in Google Scholar

Sildenafil Mesylate is an orally active and selective phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil Mesylate can be used in studies of erectile dysfunction and cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1308285-21-3
Formel: C₂₃H₃₄N₆O₇S₂
Molecular Weight:570.68

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Sildenafil Mesylate Chemical Structure

CAS. Nr.: 1308285-21-3

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Other In-stock Forms of Sildenafil Mesylate

Sildenafil

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

Sildenafil Mesylate is an orally active and selective phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil Mesylate can be used in studies of erectile dysfunction and cancer^[1].

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 1308285-21-3
Molecular Weight 570.68
Formel C₂₃H₃₄N₆O₇S₂
SMILES

CCOC1=C(C(N2)=NC3=C(N(C)N=C3CCC)C2=O)C=C(S(=O)(N4CCN(C)CC4)=O)C=C1.CS(=O)(O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (18)

All Bio/Physico-chemical AssayRT-PCRIn Vivo Efficacy StudyWBIF

Sort by:

Journal Impact Factor

Nature

Rescuing dendritic cell interstitial motility sustains antitumour immunity. [Abstract]

2025 Sep;645(8079):244-253. PMID: 40562926

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253. [Abstract]

The mean velocities of immature BMDCs in 3D collagen gel treated with vehicle, 30 μM Sildenafil or sildenafil plus 10 μM ODQ. From left to right, n = 98, 79, 126 cells.

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253. [Abstract]

Tumour growth and survival curves of MC38-Pde5−/− tumour-bearing mice treated with vehicle or Sildenafil (20 μg/g).
Phytomedicine

Crocin inhibits neutrophil migration and activation to treat hypoxic pulmonary hypertension through targeting HCK. [Abstract]

2025 Sep 25:148:157334. PMID: 41043333
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Br J Pharmacol

Sinapine thiocyanate (ST) ameliorates endothelial cell dysfunction by targeting chloride intracellular channel 4 (CLIC4) to treat hypoxia-induced pulmonary hypertension. [Abstract]

2026 Sep 30. PMID: 42817595
Br J Pharmacol

An adenosinergic positive feedback loop extends pharmacological cardioprotection duration. [Abstract]

2024 Dec;181(23):4920-4936. PMID: 39256947
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Bioeng Transl Med

Ultrasound-targeted microbubble destruction mediates PDE5i/NO integration for cavernosum remodeling and penile rehabilitation. [Abstract]

2023 Jul 2;8(5):e10568. PMID: 37693040
Int J Mol Sci

A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Activates Autophagy in Primary Skin Fibroblasts. [Abstract]

2022 Jun 20;23(12):6860. PMID: 35743299

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 20;23(12):6860. [Abstract]

P62 mRNA levels in NHF upon Sildenafil treatment (100 μM, 6 h) in presence or absence of ConA (2.5 nM, 2 h).

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 20;23(12):6860. [Abstract]

Analysis of the autophagic flux in NHF upon treatment with Sildenafil (100 μM, 24 h) in presence or absence of ConA (2.5 nM; 2 h).
ACS Omega

Computational Approaches to Identify Molecules Binding to Mycobacterium tuberculosis KasA. [Abstract]

2020 Nov 15;5(46):29935-29942. PMID: 33251429
Biochim Biophys Acta Mol Basis Dis

OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes. [Abstract]

2024 Mar;1870(3):167018. PMID: 38185350
Saudi Pharm J

Fisetin alleviates pulmonary arterial hypertension by inhibiting the TGF-β1/Smad 2/3 signaling pathway. [Abstract]

2026 Jun 25;34(3):39. PMID: 42347890
J Biol Chem

2026 Jul 24;302(9):113357. PMID: 42492813
Fitoterapia

2026 Aug 18:194:107445. PMID: 42612880
J Nat Med

Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor. [Abstract]

2025 Sep;79(5):1154-1166. PMID: 40581895
Biochem Biophys Res Commun

Lactic acid inhibits iNKT cell functions via a phosphodiesterase-5 dependent pathway. [Abstract]

2021 Apr 2:547:9-14. PMID: 33588236
Physiol Rep

β3 adrenergic agonism: A novel pathway which improves right ventricular-pulmonary arterial hemodynamics in pulmonary arterial hypertension. [Abstract]

2023 Jan;11(1):e15549. PMID: 36597221

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Physiol Rep. 2023 Jan;11(1):e15549. [Abstract]

The index of cell proliferation in the lungs is significantly reduced in hypoxic mice that received CL316243, Sildenafil (50 mg/kg), or riociguat compared with hypoxic mice treated with vehicle.
Biomed Chromatogr

A novel standard-free detection of adulteration method for sildenafil derivatives in dietary supplements. [Abstract]

2024 Aug;38(8):e5925. PMID: 38837800
bioRxiv

2026 Jul 7.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Haider M, et al. The Potential Role of Sildenafil in Cancer Management through EPR Augmentation. J Pers Med. 2021 Jun 21;11(6):585. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Sildenafil Mesylate

18 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
Chemical Information
Publications (18)
Reinheit & Dokumentation
Verweise

1/16
1/16

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253. [Abstract]

Customer Validation
The mean velocities of immature BMDCs in 3D collagen gel treated with vehicle, 30 μM Sildenafil or sildenafil plus 10 μM ODQ. From left to right, n = 98, 79, 126 cells.
1/16

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253. [Abstract]

Customer Validation
Tumour growth and survival curves of MC38-Pde5−/− tumour-bearing mice treated with vehicle or Sildenafil (20 μg/g).
1/16

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Physiol Rep. 2023 Jan;11(1):e15549. [Abstract]

Customer Validation
The index of cell proliferation in the lungs is significantly reduced in hypoxic mice that received CL316243, Sildenafil (50 mg/kg), or riociguat compared with hypoxic mice treated with vehicle.
1/16

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 20;23(12):6860. [Abstract]

Customer Validation
P62 mRNA levels in NHF upon Sildenafil treatment (100 μM, 6 h) in presence or absence of ConA (2.5 nM, 2 h).
1/16

Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 20;23(12):6860. [Abstract]

Customer Validation
Analysis of the autophagic flux in NHF upon treatment with Sildenafil (100 μM, 24 h) in presence or absence of ConA (2.5 nM; 2 h).

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Sildenafil Mesylate

Other In-stock Forms of Sildenafil Mesylate

Publications Citing Use of MedChemExpress (MCE) Sildenafil Mesylate

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Chemical Information

Publications (18)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bioz

Keywords

Your Recently Viewed Products

Sildenafil Mesylate

Other In-stock Forms of Sildenafil Mesylate

Publications Citing Use of MedChemExpress (MCE) Sildenafil Mesylate

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Chemical Information

Publications (18)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs