SNIPER(ER)-110
SNIPER(ER)-110 consists of a IAP ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively.
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- CAS. Nr.: 2241690-03-7
- Formel: C66H83N5O11
- Molecular Weight:1122.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | DC50 |
<3 nM
Compound: 6; SNIPER(ER)-110
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Protac activity at ERalpha/XIAP in human MCF7 cells assessed as induction of ERalpha degradation after 4 hrs by Western blot analysis
Protac activity at ERalpha/XIAP in human MCF7 cells assessed as induction of ERalpha degradation after 4 hrs by Western blot analysis
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[PMID: 31047748] |
Chemical Information
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CAS. Nr. 2241690-03-7
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Molecular Weight 1122.39
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Formel C66H83N5O11
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SMILES
O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@@H](NC)C)=O)=O)C[C@@H](OC3=CC=CC(OCCOCCOCCOCC(N(C)CCOC4=CC=C(/C(C5=CC=C(O)C=C5)=C(C6=CC=CC=C6)/CC)C=C4)=O)=C3)C1)N[C@@H]7CCCC8=C7C=CC=C8
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SNIPER(ER)-110 Related Classifications
HY-122825 Related Classifications
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