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Art. -Nr.: HY-100682

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T-3256336

T-3256336 is a potent and orally active cIAP1 and XIAP inhibitor with IC₅₀s of 1.3, 200 nM, respectively. T-3256336 shows anti-tumor activity.

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CAS. Nr.: 1266227-69-3
Formel: C₃₁H₄₅F₂N₅O₅
Molecular Weight:605.72

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

T-3256336 Chemical Structure

CAS. Nr.: 1266227-69-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

T-3256336 is a potent and orally active cIAP1 and XIAP inhibitor with IC₅₀s of 1.3, 200 nM, respectively. T-3256336 shows anti-tumor activity^[1].

IC₅₀ & Target^[1]

cIAP1

1.3 nM (IC₅₀)

XIAP

200 nM (IC₅₀)

Alle IAP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	GI₅₀	1.8 nM Compound: 45, T-3256336	Growth inhibition of human MDA-MB-231 cells assessed as cell viability after 3 days by CellTitre-Glo Luminescent assay Growth inhibition of human MDA-MB-231 cells assessed as cell viability after 3 days by CellTitre-Glo Luminescent assay	[PMID: 23298277]

In Vivo

T-3256336 (compound 45) (30, 100 mg/kg; p.o.) increases caspase-3/7 activity and shows anti-tumoe activity in mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female BALB/cAJcl mice (MDA-MB-231-Luc xenograft)^[1]
Dosage:

30, 100 mg/kg
Administration:

P.o.
Result:

Stimulated caspase-3/7 activity in a dose-dependent manner, induced tumor regression in a dose-dependent manner with a percent tumor growth inhibition (T/C) of 53% and 62% at 30 mg/kg and 100 mg/kg, respectively.

Chemical Information

CAS. Nr. 1266227-69-3
Appearance Solid
Molecular Weight 605.72
Formel C₃₁H₄₅F₂N₅O₅
Color White to off-white
SMILES

O=C([C@H]1N(C([C@H](C2CCC(F)(F)CC2)NC([C@@H](NC)C)=O)=O)C[C@](C[C@@H](OCC)C3)([H])N3C1)N[C@@H]4CCOC5=CC=CC=C45
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hashimoto K, et al. Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic. J Med Chem. 2013 Feb 14;56(3):1228-46. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

T-3256336

Alle IAP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

T-3256336 Related Classifications

HY-100682 Related Classifications