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Art. -Nr.: HY-120867

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TASP0376377

TASP0376377 is a potent and selective CRTH2 antagonist (IC₅₀: 13 nM). TASP0376377 has binding affinity for CRTH2 (IC₅₀: 19 nM).

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CAS. Nr.: 1233246-60-0
Formel: C₂₅H₁₆Cl₂N₂O₄
Molecular Weight:479.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TASP0376377 Chemical Structure

CAS. Nr.: 1233246-60-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

TASP0376377 is a potent and selective CRTH2 antagonist (IC₅₀: 13 nM). TASP0376377 has binding affinity for CRTH2 (IC₅₀: 19 nM)^[1].

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	19 nM Compound: 15-20, TASP0376377	Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysis Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysis	[PMID: 24216094]
CHO	IC₅₀	19 nM Compound: 6m, TASP0376377	Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cells Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cells	[PMID: 22469703]

Chemical Information

CAS. Nr. 1233246-60-0
Molecular Weight 479.31
Formel C₂₅H₁₆Cl₂N₂O₄
SMILES

O=C(NC1=CC=C(C=C1)C(C2=NC=C(C3=C2C=CC=C3)CC(O)=O)=O)C4=CC=C(C(Cl)=C4)Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nishikawa-Shimono R, et al. Isoquinoline derivatives as potent CRTH2 antagonists: design, synthesis and SAR. Bioorg Med Chem. 2013 Dec 15;21(24):7674-85. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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Chemical Information
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TASP0376377

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

TASP0376377 Related Classifications

HY-120867 Related Classifications