TG6-129
TG6-129 is a selective antagonist of the EP2 receptor. TG6-129 reduces the expression of inflammatory factors induced by butaprost in P388D1 macrophages.
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- CAS. Nr.: 1164464-14-5
- Formel: C20H18FN5O3S3
- Molecular Weight:491.58
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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EP |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C6 | CC50 |
326 μM
Compound: 1, TG6-129, 17503974
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Cytotoxicity against rat C6 cells after 48 hrs
Cytotoxicity against rat C6 cells after 48 hrs
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[PMID: 23914286] |
| C6 | IC50 |
1.6 μM
Compound: 1, TG6-129, 17503974
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Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay
Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay
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[PMID: 23914286] |
Chemical Information
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CAS. Nr. 1164464-14-5
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Molecular Weight 491.58
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Formel C20H18FN5O3S3
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SMILES
O=C(NC(NC1=CC=C(S(=O)(NC2=NN=C(CC)S2)=O)C=C1)=S)/C=C/C3=CC=C(F)C=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TG6-129 Related Classifications
HY-18970 Related Classifications
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