TH023
TH023 is an inhibitor for the TLR4 signaling pathway, that targets especially the formation of TLR4 homodimer. TH023 inhibits secreted embryonic alkaline phosphatase in cell HEK-Blue hTLR4 with an IC50 of 0.354 μM, and inhibits the NO expression in RAW264.7 with an IC50 of 1.61μM. TH023 also inhibits the activation of NF-κB, reduces the nuclear translocation of NF-κB p65. TH023 exhibits anti-inflammatory efficacy in LPS (HY-D1056)-induced mouse acute sepsis model, and ameliorates the mouse lung injury.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C22H21ClF2N4O
- Molecular Weight:430.88
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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Molecular Weight 430.88
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Formel C22H21ClF2N4O
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SMILES
O=C(C1=C2N=C(C3=CC=C(Cl)C=C3)C=C(C(F)F)N2N=C1)N4C[C@]5([H])CCCC[C@]5([H])C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TH023 Related Classifications
HY-168207 Related Classifications
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