TP-004
Based on 1 publication(s) in Google Scholar
TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM against MetAP2. TP-004 is a chemical probe. TP-004 suppresses MetAP2 enzymatic activity, blocks N-terminal methionine cleavage, impairs protein maturation and stability, and thereby inhibits cell proliferation and angiogenesis. TP-004 can be used for the study of tumors and diseases associated with excessive angiogenesis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.17%
- CAS. Nr.: 1454299-21-8
- Formel: C17H16F3N5O
- Molecular Weight:363.34
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Publications Citing Use of MedChemExpress (MCE) TP-004
More
Biologische Aktivität
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MetAp2 6 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | EC50 |
0.015 μM
Compound: 38
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Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method
Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method
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[PMID: 27155900] |
| Sf9 | IC50 |
0.005 μM
Compound: 38
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Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured for 10 to 30 mins by fluorescence plate reader analysis
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured for 10 to 30 mins by fluorescence plate reader analysis
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[PMID: 27155900] |
TP-004 inhibits methionine aminopeptidase 2 (MetAP2) with an IC50 of 6 nM[1].
TP-004 blocks N-terminal methionine cleavage mediated by MetAP2, suppresses protein maturation and stability, and inhibits cell proliferation and angiogenesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1454299-21-8
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Appearance Solid
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Molecular Weight 363.34
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Formel C17H16F3N5O
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Color Light yellow to khaki
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SMILES
O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (688.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7522 mL | 13.7612 mL | 27.5224 mL | 68.8061 mL |
| 5 mM | 0.5504 mL | 2.7522 mL | 5.5045 mL | 13.7612 mL | |
| 10 mM | 0.2752 mL | 1.3761 mL | 2.7522 mL | 6.8806 mL | |
| 15 mM | 0.1835 mL | 0.9174 mL | 1.8348 mL | 4.5871 mL | |
| 20 mM | 0.1376 mL | 0.6881 mL | 1.3761 mL | 3.4403 mL | |
| 25 mM | 0.1101 mL | 0.5504 mL | 1.1009 mL | 2.7522 mL | |
| 30 mM | 0.0917 mL | 0.4587 mL | 0.9174 mL | 2.2935 mL | |
| 40 mM | 0.0688 mL | 0.3440 mL | 0.6881 mL | 1.7202 mL | |
| 50 mM | 0.0550 mL | 0.2752 mL | 0.5504 mL | 1.3761 mL | |
| 60 mM | 0.0459 mL | 0.2294 mL | 0.4587 mL | 1.1468 mL | |
| 80 mM | 0.0344 mL | 0.1720 mL | 0.3440 mL | 0.8601 mL | |
| 100 mM | 0.0275 mL | 0.1376 mL | 0.2752 mL | 0.6881 mL |
TP-004 Related Classifications
HY-120868 Related Classifications
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