TRV055
Based on 1 Customer Validation
TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses[1]
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Sealed storage, away from moisture and light, under nitrogen.
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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AT1 Receptor |
TRV055 (1 μM) induces collagen secretion in adult rat myofibroblasts[1].
TRV055 (200 nM, 24 h) induces fibroblast proliferation, upregulates collagen I and α-SMA protein expression, and promotes stress fibre formation in human cardiac fibroblasts[2].
TRV055 (200 nM, 24 h) upregulates the synthesis and secretion of TGF-β1 in human cardiac fibroblasts through the AT1 receptor/Gαq cascade[2].
TRV055 (200 nM, 30 min) promotes ERK1/2 phosphorylation in human cardiac fibroblasts, and this effect is inhibited by blockade of TGF-β signalling[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human cardiac fibroblasts
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Concentration:200 nM
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Incubation Time:0.5, 24 h
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Result:Upregulated collagen I and α-SMA protein expression.
Promoted ERK1/2 phosphorylation.
Chemical Information
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CAS. Nr. 25849-90-5
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Appearance Solid
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Molecular Weight 831.96
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Formel C42H57N9O9
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Color White to off-white
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Synonyms
TRV120055
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Sequence Shortening
GVYIHPF
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Lösungsmittel & Löslichkeit
H2O : 33.33 mg/mL (40.06 mM; ultrasonic and adjust pH to 2 with 1M HCl)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Dallagnol JCC, et al. G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts. ACS Chem Biol. 2023 Sep 15;18(9):2050-2062. [Content Brief]
[2]. Parichatikanond W, et al. Gαq protein-biased ligand of angiotensin II type 1 receptor mediates myofibroblast differentiation through TGF-β1/ERK axis in human cardiac fibroblasts. Eur J Pharmacol. 2023 Jul 15;951:175780. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2020 mL | 6.0099 mL | 12.0198 mL | 30.0495 mL |
| 5 mM | 0.2404 mL | 1.2020 mL | 2.4040 mL | 6.0099 mL | |
| 10 mM | 0.1202 mL | 0.6010 mL | 1.2020 mL | 3.0050 mL | |
| 15 mM | 0.0801 mL | 0.4007 mL | 0.8013 mL | 2.0033 mL | |
| 20 mM | 0.0601 mL | 0.3005 mL | 0.6010 mL | 1.5025 mL | |
| 25 mM | 0.0481 mL | 0.2404 mL | 0.4808 mL | 1.2020 mL | |
| 30 mM | 0.0401 mL | 0.2003 mL | 0.4007 mL | 1.0017 mL | |
| 40 mM | 0.0300 mL | 0.1502 mL | 0.3005 mL | 0.7512 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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