country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-187355

Copy Link Print Information

VU6077564

VU6077564 is a reversible competitive antagonist of M1 mAChR, with an IC₅₀ of 31 nM in human (CHO cells) and 39.5 nM in rats. VU6077564 promotes axon growth of sensory neurons from adult rat dorsal root ganglia cultured in vitro. VU6077564 can be used for the research of peripheral neuropathy.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₆H₂₇FN₆O₃S
Molecular Weight:522.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

VU6077564 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

mAChR1

Alle mAChR Isoform-spezifische Produkte anzeigen :

In Vitro

VU6077564 potently and selectively inhibits the human M₁ muscarinic acetylcholine receptor in hM₁-CHO cells, with an hM₁ IC₅₀ of 31 nM^[1].
VU6077564 (10-point serial dilution curves) potently inhibits rat M₁ muscarinic acetylcholine receptors, with an rM₁ IC₅₀ of 39.5 nM and an rM₁ K_B of 12 nM^[1].
VU6077564 (0-1000 nM; 42 h) promotes axonal growth in cultured adult rat DRG sensory neurons, with an ED₅₀ of 55 nM. It achieves a maximum 2-fold induction effect at 1000 nM without reducing neuronal viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL_plasma	V_ss	T_1/2 (Elimination)
Rat^[1]	0.2 mg/kg	i.v.	71.7 mL/min/kg	27.6 L/kg	35.2 h

Chemical Information

Molecular Weight 522.59
Formel C₂₆H₂₇FN₆O₃S
SMILES

O=S(C1=C2C=CC=NC2=C(F)C=C1)(N[C@H]3C[C@@H](C(N4[C@@H](C)CN(C5=NC(C)=C(C#N)C=C5)CC4)=O)C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Berida TI, et al. Discovery of VU6077564: A Selective M Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons. ACS chemical neuroscience. 2026 Jul 15;17(14):2739-2751. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

VU6077564

Alle mAChR Isoform-spezifische Produkte anzeigen