Art. -Nr.: HY-N0399

Wogonoside

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway.

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Reinheit: 99.91%
CAS. Nr.: 51059-44-0
Formel: C₂₂H₂₀O₁₁
Molecular Weight:460.39

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Wogonoside Chemical Structure

CAS. Nr.: 51059-44-0

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	IC₅₀	>1000 μM Compound: 4	Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA	[PMID: 9214730]

In Vitro

Wogonoside (0-50 μM, 24 h) inhibits the production of inflammatory mediators (NO, PGE2), and pro-inflammatory cytokines (TNF-α and IL-6) in LPS-induced RAW264.7 cells^[1].
Wogonoside (0-400 μM, 24 h) inhibits growth of MDA-MB-231 and MCF-7^[2].
Wogonoside (100 μM, 9-24 h) induces autophagy in MDA-MB-231 cells^[2].
Wogonoside (50-150 μM, 48-96 h) inhibits proliferation, induces G1 phase arrest, and differentiation in U937 and HL-60 cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

MDA-MB-231 cells
Concentration:

100 μM
Incubation Time:

9-24 h
Result:

Increased the expression of LC3-II and Beclin-1 expression.
Inhibited the phosphorylation levels of mTOR at Ser2448 and p70S6K at Ser-389.

In Vivo

Wogonoside (80 mg/kg, oral gavage, once every other day) inhibits tumor growth and metastasis in MDA-MB-231 orthotopic model^[3].
Wogonoside (40 or 80 mg/kg, i.p., every three days) inhibits tumor growth and reduces Bcl-2/Bax ratio in A549 cell xenograft mice^[4].
Wogonoside (80 mg/kg, i.P., every other day for 14 days) also inhibits tumor growth in U937 xenograft model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MDA-MB-231 orthotopic model^[3]
Dosage:

80 mg/kg
Administration:

oral gavage, once every other day
Result:

Inhibited tumor growth (46%) and metastasis in brain, lung, liver and bone.
Increased the expression of E-cadherin and reduced the expression of MMP-9, vimentin and Twist1 at orthotopic site.

Chemical Information

CAS. Nr. 51059-44-0
Appearance Solid
Molecular Weight 460.39
Formel C₂₂H₂₀O₁₁
Color Light yellow to yellow
SMILES

O=C(C=C(C1=CC=CC=C1)O2)C3=C2C(OC)=C(O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O)C=C3O
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Monophenols
Initial Source
- Plants
- Labiatae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

All Cell Proliferation/Viability Assay

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Journal Impact Factor

Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Cell Death Discov

NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer. [Abstract]

2025 Nov 10;11(1):520. PMID: 41213930

Wogonoside purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Nov 10;11(1):520. [Abstract]

CCK-8 assay to detect the inhibitory effect of NRG1 on cell death induced by Erastin, Nigericin, Hydroxyurea, and Wogonoside in BC cells.
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 Oct 15:489:144992. PMID: 40466530

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (271.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1721 mL

10.8604 mL

21.7207 mL

5 mM

0.4344 mL

2.1721 mL

4.3441 mL

10 mM

0.2172 mL

1.0860 mL

2.1721 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang YZ, et al. Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells. J Ethnopharmacol. 2013 Jun 21;148(1):271-6. [Content Brief]

[2]. Sun Y, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013 Jan;51:53-60. [Content Brief]

[3]. Yao Y, et al. Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer. J Exp Clin Cancer Res. 2017 Aug 3;36(1):103. [Content Brief]

[4]. Luo M, et al. Wogonoside induces apoptosis in human non-small cell lung cancer A549 cells by promoting mitochondria dysfunction. Biomed Pharmacother. 2018 Oct;106:593-598. [Content Brief]

[5]. Chen Y, et al. Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells. Blood. 2013 May 2;121(18):3682-91. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1721 mL	10.8604 mL	21.7207 mL	54.3018 mL
	5 mM	0.4344 mL	2.1721 mL	4.3441 mL	10.8604 mL
	10 mM	0.2172 mL	1.0860 mL	2.1721 mL	5.4302 mL
	15 mM	0.1448 mL	0.7240 mL	1.4480 mL	3.6201 mL
	20 mM	0.1086 mL	0.5430 mL	1.0860 mL	2.7151 mL
	25 mM	0.0869 mL	0.4344 mL	0.8688 mL	2.1721 mL
	30 mM	0.0724 mL	0.3620 mL	0.7240 mL	1.8101 mL
	40 mM	0.0543 mL	0.2715 mL	0.5430 mL	1.3575 mL
	50 mM	0.0434 mL	0.2172 mL	0.4344 mL	1.0860 mL
	60 mM	0.0362 mL	0.1810 mL	0.3620 mL	0.9050 mL
	80 mM	0.0272 mL	0.1358 mL	0.2715 mL	0.6788 mL
	100 mM	0.0217 mL	0.1086 mL	0.2172 mL	0.5430 mL

Keywords

Wogonoside

3 Cited Publications

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Wogonoside

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Autophagy Compound Library

Publications Citing Use of MedChemExpress (MCE) Wogonoside

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Wogonoside Related Classifications

HY-N0399 Related Classifications