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Art. -Nr.: HY-178976

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YL6113

YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC₅₀ values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC₅₀ values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₈H₁₈BClN₄O₅
Molecular Weight:416.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

YL6113 Chemical Structure

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Preis

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Menge

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

KPC-2

0.2 μM (IC₅₀)

NDM-1

0.25 μM (IC₅₀)

OXA-48

1.31 μM (IC₅₀)

IMP-1

3.55 μM (IC₅₀)

VIM-2

27.16 μM (IC₅₀)

AmpC

34.1 μM (IC₅₀)

Alle Beta-lactamase Isoform-spezifische Produkte anzeigen :

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	T_max	AUC_0-t	MRT_0-t	V_z	Cl_{F_obs}
Rat^[1]	10 mg/kg	i.p.	0.88 h	4779.52 μg/L	0.08 h	3670.17 μg/L·h	1.01 h	3.46 L/kg	2.72 L/h/kg

In Vivo

YL6113 (10 mg/kg; IP; single dose) significantly reduces bacterial load in a murine sepsis modell when combined with Meropenem (HY-13678)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Murine sepsis model infected with NDM-1-producing K.p. 140509 strain^[1]
Dosage:

10 mg/kg
Administration:

Ip, a single dose
Result:

Significantly reduced bacterial load in the lungs, liver, and kidneys compared to the control and Meropenem-only groups.

Chemical Information

Molecular Weight 416.62
Formel C₁₈H₁₈BClN₄O₅
SMILES

NCC1=CC=C(C=C1)C2=CN(N=N2)CC3=CC=C4OCB(OC4=C3C(O)=O)O.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang ZB, et al. Structural Optimization of Bicyclic Oxo-Boronates as Dual Metallo- and Serine-β-Lactamase Inhibitors. J Med Chem. 2025 Oct 23;68(20):21807-21828. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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YL6113

Alle Beta-lactamase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

YL6113 Related Classifications

HY-178976 Related Classifications