Actithiazic acid
Actithiazic acid is a thiazolidinone antibiotic that targets biotin synthase. Actithiazic acid interferes with essential bacterial metabolism by inhibiting the final step of biotin synthesis (conversion of desthiobiotin to biotin, IC50 = 0.45 μM). Actithiazic acid can be used in studies related to mycobacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 539-35-5
- Formula: C9H15NO3S
- Molecular Weight:217.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Antibiotic Isoforms
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Biological Activity
Actithiazic acid (0.45-3.9 μM; 20 min) inhibits the enzymatic conversion of desthiobiotin to biotin in resting cell suspensions of Escherichia coli K-12 strain ABD313-136, with an IC50 of 0.45 μM[1].
Actithiazic acid (1 μg/mL) induces derepression of the biotin A operon in Escherichia coli K-12 strain Y10-1, with the maximum enhancement of 7,8-diaminopelargonic acid aminotransferase and desthiobiotin synthetase activities observed at the concentration of 1 μg/mL[1].
Actithiazic acid promotes the excretion of biotin-like substances in growth cultures of Escherichia coli and various other microorganisms[1].
Combination of actithiazic acid (10-50 μg/mL; 18 h) with Cephalexin (HY-B0200) exerts moderate synergistic effects against *Escherichia coli* 9632 in nutrient broth[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 539-35-5
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Molecular Weight 217.29
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Formula C9H15NO3S
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SMILES
O=C(CCCCCC1SCC(N1)=O)O
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Synonyms
Mycobacidin; Cinnamonin; Acidomycin
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)