SCARB1 - scavenger receptor class B member 1 Gene
Also Known as CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6
Species: Homo sapiens
About SCARB1
This gene has 22 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in adrenal (RPKM 333.6), placenta (RPKM 91.6) and 4 other tissues.
Summary
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein Cholesterol (HDL). The encoded protein mediates Cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]
SCARB1 Products (11)
| mRNA | Protein | Name |
|---|---|---|
| NM_001082959.2 | NP_001076428.1 | scavenger receptor class B member 1 isoform 2 |
| NM_001367981.1 | NP_001354910.1 | scavenger receptor class B member 1 isoform 3 |
| NM_001367982.1 | NP_001354911.1 | scavenger receptor class B member 1 isoform 4 |
| NM_001367983.1 | NP_001354912.1 | scavenger receptor class B member 1 isoform 5 |
| NM_001367984.1 | NP_001354913.1 | scavenger receptor class B member 1 isoform 6 |
| NM_001367985.1 | NP_001354914.1 | scavenger receptor class B member 1 isoform 7 |
| NM_001367986.1 | NP_001354915.1 | scavenger receptor class B member 1 isoform 8 |
| NM_001367987.1 | NP_001354916.1 | scavenger receptor class B member 1 isoform 9 |
| NM_001367988.1 | NP_001354917.1 | scavenger receptor class B member 1 isoform 10 |
| NM_001367989.1 | NP_001354918.1 | scavenger receptor class B member 1 isoform 1 |
| NM_005505.5 | NP_005496.4 | scavenger receptor class B member 1 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables apolipoprotein A-I binding |
IPI
IPI: Inferred from physical interaction
|
10764676 | GOA |
| enables apolipoprotein binding |
IPI
IPI: Inferred from physical interaction
|
10764676 | GOA |
| enables high-density lipoprotein particle receptor activity |
IDA
IDA: Inferred from direct assay
|
9211901 | GOA |
| enables high-density lipoprotein particle receptor activity |
IMP
IMP: Inferred from mutant phenotype
|
11208913 | GOA |
| enables lipopolysaccharide binding |
IDA
IDA: Inferred from direct assay
|
12651854 | GOA |
| enables lipopolysaccharide immune receptor activity |
IDA
IDA: Inferred from direct assay
|
12651854 | GOA |
| enables low-density lipoprotein particle binding |
IDA
IDA: Inferred from direct assay
|
9211901 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12356718 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
9211901 | GOA |
SCARB1 Protein Structure
CD36: CD36 family (15 - 465)
- 0
- 100
- 200
- 300
- 400
- 500
- 552 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
scavenger receptor class B member 1 |
|
SCARB1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SCARB1 | Q8WTV0 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
SCARB1 | Q8WTV0 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Cross
|
SCARB1 | Q8WTV0 | P0DTD1-PRO_0000449625 | SARS-CoV-2 | P0DTD1-PRO_0000449625 | 36217030 | |
|
Intra
|
SCARB1 | Q8WTV0 | CD81 | Homo sapiens | P60033 | 32900848 | |
|
Intra
|
SCARB1 | Q8WTV0 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
SCARB1 | Q8WTV0 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
SCARB1 | Q8WTV0 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Cross
|
SCARB1 | Q8WTV0 | P27958-PRO_0000037570 | Hepatitis C virus | P27958-PRO_0000037570 | 12356718 |
Recombinant SCARB1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P76656 | SR-BI/SCARB1 Protein, Human (HEK293, Fc) | Q8WTV0-1/NP_001076428.1 (P33-Y443) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P76657 | SR-BI/SCARB1 Protein, Human (HEK293, His) | Q8WTV0-1/NP_001076428.1 (P33-Y443) | ≥ 95%, as determined by reducing Bis-Tris PAGE. |
| HY-P76658 | SR-BI/SCARB1 Protein, Human (HEK293, His-Fc) | Q8WTV0-1/NP_001076428.1 (P33-Y443) | ≥ 95%, as determined by reducing SDS-PAGE. |
SCARB1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81415 | SCARB1 Antibody (YA1160) | IHC-P | Human |
| HY-P81415A | SCARB1 Antibody (YA1160)(PBS only) | IHC-P | Human |
| HY-P82163 | SCARB1 Antibody (YA1908) | WB, IP | Human, Mouse |
| HY-P82163A | SCARB1 Antibody (YA1908)(PBS only) | WB, IP | Human, Mouse |
| HY-P84687 | SCARB1 Antibody (YA4384) | WB, IHC-P, FC, ELISA | Human |
| HY-P84687A | SCARB1 Antibody (YA4384)(PBS only) | WB, IHC-P, FC, ELISA | Human |
| HY-P84688 | SCARB1 Antibody (YA4385) | WB, IHC-P, FC, ELISA | Human, Mouse |
| HY-P84688A | SCARB1 Antibody (YA4385)(PBS only) | WB, IHC-P, FC, ELISA | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6 |
|
|
| Hepatitis C |
|
|
| Hepatitis C Virus |
|
|
| Hepatitis |
|
|
| Hyperalphalipoproteinemia 1 |
|
|
| Platelet Glycoprotein Iv Deficiency |
|
|
| Cholelithiasis |
|
|
| Atherosclerosis Susceptibility |
|
|
| Malaria |
|
|
| Aortic Atherosclerosis |
|
|
| Coronary Stenosis |
|
|
| Familial Hyperlipidemia |
|
|
| Non-Alcoholic Fatty Liver Disease |
|
|
| Familial Hypercholesterolemia |
|
|
| Lipid Metabolism Disorder |
|
|
| Fatty Liver Disease |
|
|
| Hypolipoproteinemia |
|
|
| Glycogen Storage Disease |
|
|
| Cardiovascular System Disease |
|
|
| Myocardial Infarction |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Adrenal Cortical Carcinoma |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Non-Alcoholic Steatohepatitis |
|
|
| Hypoalphalipoproteinemia, Primary, 1 |
|
|
| Tangier Disease |
|
|
| Acute Hemorrhagic Encephalitis |
|
|
| Sitosterolemia |
|
|
| Diabetes Mellitus |
|
|
| Lipid Storage Disease |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Overnutrition |
|
|
| Acquired Metabolic Disease |
|
|
| Hypertension, Essential |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Blood Platelet Disease |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | SCARB1 | VGNC | VGNC:45898 |
| Felis catus | SCARB1 | VGNC | VGNC:64901 |
| Mus musculus | SCARB1 | MGD | MGI:893578 |
| Macaca mulatta | SCARB1 | VGNC | VGNC:77025 |
| Bos taurus | SCARB1 | VGNC | VGNC:34324 |
| Rattus norvegicus | SCARB1 | RGD | RGD:2302 |
| Others | SCARB1 | NCBI |