RRD-251
Based on 1 Customer Validation
RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 72214-67-6
- Formula: C8H9Cl3N2S
- Molecular Weight:271.59
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Rb-Raf-1 interaction, apoptosis[1]
RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro[1].
RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells[1].
RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours)[1].
RRD-251 alters the expression of cell cycle and apoptosis regulatory protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
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Concentration:10 μM, 20 μM, 50 μM
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Incubation Time:24 hours
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Result:Inhibited melanoma growth in-vitro.
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Cell Line:SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
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Concentration:50 μM
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Incubation Time:2 hours
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Result:Showed the depletion of phosphorylated-Rb in RRD-251 treated cells.
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Cell Line:SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
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Concentration:50 μM
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Incubation Time:18 hours
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Result:Induced apoptosis.
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Cell Line:SK-MEL-28 cells , SK-MEL-5 cells
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Concentration:20 μM, 50 μM
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Incubation Time:4 hours
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Result:Resulted in a dose dependent inhibition of cell cycle progression in SK-MEL-28 and SK-MEL-5 cells, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-wk-old female athymic nude mice, with SK-ME-28 xenograft[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneal administration, qod, for 14 days
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Result:Inhibits the growth of SK-ME-28 xenograft in nude mice.
Chemical Information
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CAS No. 72214-67-6
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Appearance Solid
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Molecular Weight 271.59
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Formula C8H9Cl3N2S
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Color White to off-white
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SMILES
NC(SCC1=CC=C(Cl)C=C1Cl)=N.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (460.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6820 mL | 18.4101 mL | 36.8202 mL | 92.0505 mL |
| 5 mM | 0.7364 mL | 3.6820 mL | 7.3640 mL | 18.4101 mL | |
| 10 mM | 0.3682 mL | 1.8410 mL | 3.6820 mL | 9.2051 mL | |
| 15 mM | 0.2455 mL | 1.2273 mL | 2.4547 mL | 6.1367 mL | |
| 20 mM | 0.1841 mL | 0.9205 mL | 1.8410 mL | 4.6025 mL | |
| 25 mM | 0.1473 mL | 0.7364 mL | 1.4728 mL | 3.6820 mL | |
| 30 mM | 0.1227 mL | 0.6137 mL | 1.2273 mL | 3.0684 mL | |
| 40 mM | 0.0921 mL | 0.4603 mL | 0.9205 mL | 2.3013 mL | |
| 50 mM | 0.0736 mL | 0.3682 mL | 0.7364 mL | 1.8410 mL | |
| 60 mM | 0.0614 mL | 0.3068 mL | 0.6137 mL | 1.5342 mL | |
| 80 mM | 0.0460 mL | 0.2301 mL | 0.4603 mL | 1.1506 mL | |
| 100 mM | 0.0368 mL | 0.1841 mL | 0.3682 mL | 0.9205 mL |
RRD-251 Related Classifications
HY-117737A Related Classifications
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