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Cat. No.: HY-P11606

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WNT3Ap

WNT3Ap is a polypeptide corresponding to the hairpin 2 domain of the WNT3A protein. WNT3Ap undergoes palmitoylation modification catalyzed by PORCN. WNT3Ap is a key compound for elucidating the molecular mechanism of the Wnt signaling pathway and for developing PORCN inhibitors.

For research use only. We do not sell to patients.

Formula: C₁₀₈H₁₆₄N₃₂O₂₈S₅
Molecular Weight:2518.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WNT3Ap Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Wnt Isoforms :

In Vitro

WNT3Ap (50 μM; 37°C for 30 minutes) undergoes acylation by PORCN in vitro, with a Km value of 14.29 μM for palmitoyl-CoA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 2518.98
Formula C₁₀₈H₁₆₄N₃₂O₂₈S₅
Sequence

Met-His-Leu-Lys-Cys-Lys-Cys-His-Gly-Leu-Ser-Gly-Ser-Cys-Glu-Val-Lys-Thr-Cys-Trp-Trp-Ser-NH2 (Disulfide bridge:Cys5-Cys19,Cys7-Cys14)
Sequence Shortening

MHLKCKCHGLSGSCEVKTCWWS-NH2 (Disulfide bridge:Cys5-Cys19,Cys7-Cys14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu Y, et al. Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature. 2022;607(7920):816-822. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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WNT3Ap

All Wnt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

WNT3Ap Related Classifications

HY-P11606 Related Classifications