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Cat. No.: HY-113455

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9(S)-HODE

(Synonyms: Alpha-dimorphecolic acid)

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9(S)-HODE (Alpha-dimorphecolic acid) is the major active derivative of Linoleic acid (HY-N0729). 9(S)-HODE regulates the expression of miR-361-3p. 9(S)-HODE reduces cancer cell viability and induces cancer cell apoptosis. 9(S)-HODE can be used in the research of acute myeloid leukemia.

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Pureté: 98%
CAS No.: 73543-67-6
Formule: C₁₈H₃₂O₃
Masse moléculaire:296.44

Stockage:

Solution, -20°C, 2 years

9(S)-HODE Chemical Structure

CAS No.: 73543-67-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Human Endogenous Metabolite

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

In Vitro

9S-HODE (12.5-25 μM; 12-72 h) significantly downregulates the expression of miR-361-3p in HL-60 cells^[1].
9S-HODE (25 μM; 0-72 h) inhibits the viability of HL-60 cells and induces apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

human acute myeloid leukemia HL-60 cells
Concentration:

25 μM
Incubation Time:

12, 24, 36, 48, 72 h
Result:

Downregulated miR-361-3p expression in a time-dependent manner.
Increased BTG2 mRNA expression.

Apoptosis Analysis^[1]

Cell Line:

human acute myeloid leukemia HL-60 cells
Concentration:

25 μM
Incubation Time:

48 h
Result:

Increased the percentages of early apoptotic (Annexin V+/PI-) and late apoptotic (Annexin V+/PI+) HL-60 cells compared to control.

Chemical Information

CAS No. 73543-67-6
Appearance Liquid
Masse moléculaire 296.44
Formule C₁₈H₃₂O₃
Color Colorless to light yellow
SMILES

CCCCC/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O
Synonyms

Alpha-dimorphecolic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Solution, -20°C, 2 years

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
SDS (544 KB)
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- Korean - KR (544 KB)
- Portuguese - PT (544 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liu S, et al. Linoleic acid derivatives target miR‐361‐3p/BTG2 to confer anticancer effects in acute myeloid leukemia. Journal of Biochemical and Molecular Toxicology, 2023, 37(11): e23481.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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9(S)-HODE

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

9(S)-HODE Related Classifications

HY-113455 Related Classifications