Cat. No.: HY-10200

BMS-754807

Name: BMS-754807
Brand: MedChemExpress
SKU: HY-10200
Price: 132.00 USD
Availability: InStock
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BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC₅₀=1.8 and 1.7 nM, respectively; K_i=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC₅₀ values of 6, 44, 7, 4, 9, and 25 nM, respectively.

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Pureté: 99.42%
CAS No.: 1001350-96-4
Formule: C₂₃H₂₄FN₉O
Masse moléculaire:461.49

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Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months

BMS-754807 Chemical Structure

CAS No.: 1001350-96-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (14)
Solvant et solubilité
- In Vitro
- In Vivo
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Activité biologique

Description

IC₅₀ & Target

IC50: 1.7 nM (IR), 1.8 nM (IGF-1R), 4 nM (TrkB), 6 nM (Met), 7 nM (TrkA), 9 nM (AurA), 25 nM (AurB), 44 nM (RON)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	1.647 μM Compound: BMS-754807	Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
A2780S	IC₅₀	0.122 μM Compound: BMS-754807	Antiproliferative activity against human A2780S cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human A2780S cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
A549	IC₅₀	0.675 μM Compound: BMS-754807	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
A673	IC₅₀	0.408 μM Compound: BMS-754807	Antiproliferative activity against human A673 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human A673 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
ASPC1	IC₅₀	0.379 μM Compound: BMS-754807	Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
AU565	IC₅₀	4.97 μM Compound: BMS-754807	Antiproliferative activity against human AU565 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human AU565 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
BT-20	IC₅₀	3.562 μM Compound: BMS-754807	Antiproliferative activity against human BT-20 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human BT-20 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
BT-474	IC₅₀	2.403 μM Compound: BMS-754807	Antiproliferative activity against human BT-474 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human BT-474 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
BT-549	IC₅₀	1.645 μM Compound: BMS-754807	Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
BXPC-3	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
CAKI-1	IC₅₀	5.25 μM Compound: BMS-754807	Antiproliferative activity against human CAKI-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human CAKI-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
CAKI-2	IC₅₀	2.056 μM Compound: BMS-754807	Antiproliferative activity against human CAKI-2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human CAKI-2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
CAL-27	IC₅₀	2 μM Compound: BMS-754807	Antiproliferative activity against human CAL-27 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human CAL-27 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
Calu-6	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human Calu-6 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human Calu-6 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
Capan-2	IC₅₀	1.774 μM Compound: BMS-754807	Antiproliferative activity against human Capan-2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human Capan-2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
CCRF-CEM	IC₅₀	1.239 μM Compound: BMS-754807	Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
COLO 205	IC₅₀	0.104 μM Compound: BMS-754807	Antiproliferative activity against human COLO 205 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human COLO 205 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
COLO-320-HSR	IC₅₀	0.011 μM Compound: BMS-754807	Antiproliferative activity against human COLO 320HSR cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human COLO 320HSR cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
CWR22R	IC₅₀	0.175 μM Compound: BMS-754807	Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
Daoy	IC₅₀	1.979 μM Compound: BMS-754807	Antiproliferative activity against human Daoy cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human Daoy cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
Daudi	IC₅₀	2.637 μM Compound: BMS-754807	Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
Detroit 562	IC₅₀	1.14 μM Compound: BMS-754807	Antiproliferative activity against human Detroit 562 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human Detroit 562 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
DLD-1	IC₅₀	0.909 μM Compound: BMS-754807	Antiproliferative activity against human DLD-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human DLD-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
DU-145	IC₅₀	1.465 μM Compound: BMS-754807	Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
DU-4475	IC₅₀	2.431 μM Compound: BMS-754807	Antiproliferative activity against human DU-4475 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human DU-4475 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
EMT6	IC₅₀	0.806 μM Compound: BMS-754807	Antiproliferative activity against mouse EMT6 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against mouse EMT6 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
FaDu	IC₅₀	1.27 μM Compound: BMS-754807	Antiproliferative activity against human FaDu cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human FaDu cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HCC1419	IC₅₀	2.517 μM Compound: BMS-754807	Antiproliferative activity against human HCC1419 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HCC1419 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HCC38	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human HCC38 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HCC38 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HCC70	IC₅₀	1.55 μM Compound: BMS-754807	Antiproliferative activity against human HCC70 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HCC70 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HCT-116	IC₅₀	0.852 μM Compound: BMS-754807	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HCT-116/VM46	IC₅₀	1.702 μM Compound: BMS-754807	Antiproliferative activity against human HCT-116/VM46 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HCT-116/VM46 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HCT-15	IC₅₀	>1 μM Compound: BMS-754807	Antiproliferative activity against human HCT-15 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HCT-15 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HEK293	IC₅₀	0.915 μM Compound: BMS-754807	Antiproliferative activity against human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HepG2	IC₅₀	0.025 μM Compound: BMS-754807	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HL-60	IC₅₀	0.12 μM Compound: BMS-754807	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HPAF-II	IC₅₀	0.644 μM Compound: BMS-754807	Antiproliferative activity against human HPAF-II cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HPAF-II cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
Hs 766	IC₅₀	2.001 μM Compound: BMS-754807	Antiproliferative activity against human Hs766T cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human Hs766T cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
Hs-578T	IC₅₀	1.287 μM Compound: BMS-754807	Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
HT-29	IC₅₀	2.103 μM Compound: BMS-754807	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
IMR-32	IC₅₀	0.261 μM Compound: BMS-754807	Antiproliferative activity against human IMR-32 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human IMR-32 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
JJN-3	IC₅₀	2.433 μM Compound: BMS-754807	Antiproliferative activity against human JJN-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human JJN-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
Jurkat	IC₅₀	3.57 μM Compound: BMS-754807	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
K562	IC₅₀	2.302 μM Compound: BMS-754807	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
Kasumi 1	IC₅₀	0.16 μM Compound: BMS-754807	Antiproliferative activity against human Kasumi 1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human Kasumi 1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
KM12C	IC₅₀	0.054 μM Compound: BMS-754807	Antiproliferative activity against human KM12-C cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human KM12-C cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
L1210	IC₅₀	2.39 μM Compound: BMS-754807	Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
L2987	IC₅₀	0.442 μM Compound: BMS-754807	Antiproliferative activity against human L2987 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human L2987 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
LNCaP-Clone-FGC	IC₅₀	1.434 μM Compound: BMS-754807	Antiproliferative activity against human LNCaP clone FGC cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human LNCaP clone FGC cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
LS174T	IC₅₀	0.535 μM Compound: BMS-754807	Antiproliferative activity against human LS174T cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human LS174T cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
LS180	IC₅₀	0.696 μM Compound: BMS-754807	Antiproliferative activity against human LS180 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human LS180 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
LS-513	IC₅₀	0.135 μM Compound: BMS-754807	Antiproliferative activity against human LS-513 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human LS-513 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
M109	IC₅₀	1.055 μM Compound: BMS-754807	Antiproliferative activity against mouse M109 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against mouse M109 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MCF7	IC₅₀	0.016 μM Compound: BMS-754807	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MDA-MB-157	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MDA-MB-231	IC₅₀	1.648 μM Compound: BMS-754807	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MDA-MB-415	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human MDA-MB-415 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MDA-MB-415 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MDA-MB-435S	IC₅₀	1.869 μM Compound: BMS-754807	Antiproliferative activity against human MDA-MB-435S cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MDA-MB-435S cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MDA-MB-436	IC₅₀	5.502 μM Compound: BMS-754807	Antiproliferative activity against human MDA-MB-436 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MDA-MB-436 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MDA-MB-453	IC₅₀	1.869 μM Compound: BMS-754807	Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MDA-MB-468	IC₅₀	0.504 μM Compound: BMS-754807	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
ML-2	IC₅₀	0.09 μM Compound: BMS-754807	Antiproliferative activity against human ML-2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human ML-2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MOLM-13	IC₅₀	0.42 μM Compound: BMS-754807	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
MV4-11	IC₅₀	0.33 μM Compound: BMS-754807	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H1299	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H1437	IC₅₀	0.523 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H1437 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H1437 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H2052	IC₅₀	1.05 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H2052 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H2052 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H2087	IC₅₀	>1 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H2087 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H2087 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H209	IC₅₀	1.193 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H209 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H209 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H211	IC₅₀	0.733 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H211 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H211 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H292	IC₅₀	0.788 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H292 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H292 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H441	IC₅₀	0.646 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H441 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H441 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H446	IC₅₀	1.154 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H446 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H446 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H460	IC₅₀	0.795 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H526	IC₅₀	0.044 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H526 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H526 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H661	IC₅₀	0.573 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H661 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H661 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H838	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H838 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H838 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
NCI-H929	IC₅₀	0.014 μM Compound: BMS-754807	Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
OCI-AML2	IC₅₀	3.33 μM Compound: BMS-754807	Antiproliferative activity against human OCI-AML2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human OCI-AML2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
OCI-Ly10	IC₅₀	0.45 μM Compound: BMS-754807	Antiproliferative activity against human OCI-Ly10 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human OCI-Ly10 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
OCI-LY19	IC₅₀	0.4 μM Compound: BMS-754807	Antiproliferative activity against human OCILY19 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human OCILY19 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
OVCAR-3	IC₅₀	5 μM Compound: BMS-754807	Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
OVCAR-4	IC₅₀	1 μM Compound: BMS-754807	Antiproliferative activity against human OVCAR-4 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human OVCAR-4 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
OVCAR-5	IC₅₀	0.05 μM Compound: BMS-754807	Antiproliferative activity against human OVCAR-5 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human OVCAR-5 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
P388	IC₅₀	4.27 μM Compound: BMS-754807	Antiproliferative activity against mouse P388 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against mouse P388 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
PANC-1	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
PC-3	IC₅₀	0.965 μM Compound: BMS-754807	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
PFSK-1	IC₅₀	0.132 μM Compound: BMS-754807	Antiproliferative activity against human PFSK-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human PFSK-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
RH-1	IC₅₀	0.027 μM Compound: BMS-754807	Antiproliferative activity against human RH-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human RH-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
RPMI-8226	IC₅₀	1.293 μM Compound: BMS-754807	Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
RS4-11	IC₅₀	0.102 μM Compound: BMS-754807	Antiproliferative activity against human RS4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human RS4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SCC-15	IC₅₀	0.67 μM Compound: BMS-754807	Antiproliferative activity against human SCC-15 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SCC-15 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SCC-25	IC₅₀	0.68 μM Compound: BMS-754807	Antiproliferative activity against human SCC-25 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SCC-25 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SCC-4	IC₅₀	0.63 μM Compound: BMS-754807	Antiproliferative activity against human SCC-4 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SCC-4 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SCC-9	IC₅₀	0.75 μM Compound: BMS-754807	Antiproliferative activity against human SCC-9 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SCC-9 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SET-2	IC₅₀	0.298 μM Compound: BMS-754807	Antiproliferative activity against human SET2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SET2 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SHP77	IC₅₀	1.888 μM Compound: BMS-754807	Antiproliferative activity against human SHP77 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SHP77 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SH-SY5Y	IC₅₀	0.106 μM Compound: BMS-754807	Antiproliferative activity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SK-HEP1	IC₅₀	0.146 μM Compound: BMS-754807	Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SK-LMS-1	IC₅₀	0.687 μM Compound: BMS-754807	Antiproliferative activity against human SK-LMS-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SK-LMS-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SK-N-AS	IC₅₀	0.497 μM Compound: BMS-754807	Antiproliferative activity against human SK-N-AS cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SK-N-AS cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SK-N-SH	IC₅₀	0.139 μM Compound: BMS-754807	Antiproliferative activity against human SK-N-SH cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SK-N-SH cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SK-OV-3	IC₅₀	5.1 μM Compound: BMS-754807	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SNU-C1	IC₅₀	0.007 μM Compound: BMS-754807	Antiproliferative activity against human SNU-C1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SNU-C1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
ST486	IC₅₀	1.19 μM Compound: BMS-754807	Antiproliferative activity against human ST486 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human ST486 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SU.86.86	IC₅₀	2.672 μM Compound: BMS-754807	Antiproliferative activity against human SU-86-86 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SU-86-86 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SW 1116	IC₅₀	0.067 μM Compound: BMS-754807	Antiproliferative activity against human SW 1116 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SW 1116 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SW1990	IC₅₀	0.826 μM Compound: BMS-754807	Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SW480	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SW626	IC₅₀	2.306 μM Compound: BMS-754807	Antiproliferative activity against human SW626 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SW626 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SW684	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human SW684 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SW684 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
SW872	IC₅₀	1.02 μM Compound: BMS-754807	Antiproliferative activity against human SW872 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human SW872 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
T98G	IC₅₀	1.218 μM Compound: BMS-754807	Antiproliferative activity against human T98G cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human T98G cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
TALL-1	IC₅₀	1.28 μM Compound: BMS-754807	Antiproliferative activity against human TALL-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human TALL-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
TC-32	IC₅₀	0.008 μM Compound: BMS-754807	Antiproliferative activity against human TC-32 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human TC-32 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
THP-1	IC₅₀	6.58 μM Compound: BMS-754807	Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
TOV112D	IC₅₀	2.146 μM Compound: BMS-754807	Antiproliferative activity against human TOV112D cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human TOV112D cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
TOV21G	IC₅₀	4.279 μM Compound: BMS-754807	Antiproliferative activity against human TOV-21G cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human TOV-21G cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
U-118-MG	IC₅₀	1.618 μM Compound: BMS-754807	Antiproliferative activity against human U-118-MG cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human U-118-MG cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
U-266	IC₅₀	1.669 μM Compound: BMS-754807	Antiproliferative activity against human U266B1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human U266B1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
U-87MG ATCC	IC₅₀	0.95 μM Compound: BMS-754807	Antiproliferative activity against human U87 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human U87 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
U-937	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
WiDr	IC₅₀	0.076 μM Compound: BMS-754807	Antiproliferative activity against human WiDr cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human WiDr cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
ZR-75-1	IC₅₀	2.084 μM Compound: BMS-754807	Antiproliferative activity against human ZR-75-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human ZR-75-1 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]
ZR-75-30	IC₅₀	>5 μM Compound: BMS-754807	Antiproliferative activity against human ZR-75-30 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay Antiproliferative activity against human ZR-75-30 cells assessed as inhibition of cell growth incubated for 72 hrs by 3H-thymidine incorporation assay	[PMID: 19996272]

In Vitro

BMS-754807 effectively inhibits the growth of a broad range of human tumor cell lines with IC₅₀ values of ranging from 5 to 365 nM. BMS-754807 also inhibits the proliferation of human rhabdomyosarcoma tumor cells Rh41 and human colon carcinoma Geo with IC₅₀s of 7 and 5 nM, respectively. BMS-754807 shows inhibitory activity in the proliferation of Rh41 cells with IC₅₀ of 5 nM^[1]. BMS-754807 inhibits the phosphorylation of IGF-1R (IC₅₀=13 nM) and the downstream targets Akt (IC₅₀=22 nM) and MAPK (IC₅₀=13 nM) in the IGF-Sal cell line with IC₅₀ consistent with the antiproliferative IC₅₀ (7 nM) in this cell line^[2]. BMS-754807 shows a median EC₅₀ value of 0.62 μM against the PPTP cell lines. The median EC₅₀ for the four Ewing sarcoma cell lines is less than that for the remaining PPTP cell lines (0.19 μM vs. 0.78 μM, P=0.0470)^[3]. BMS-754807 (0.25 and 0.5 μM) reduces the activated IGF-IR/IR (pIGF-IR/IR), causes a concurrent decrease in phosphorylated AKT in both lung cancer cell lines. BMS-754807 (0.5 μM) also reduces wound closure of lung cancer cells and reduces the ERK phosphorylation. BMS-754807 reduces cell viability in both A549 and NCI-H358 cells, with IC₅₀ of 1.08 μM and 76 μM, respectively^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BMS-754807 (3.125 and 12.5 mg/kg, p.o.) inhibits tumor growth in IGF-1R-Sal tumor-bearing nude mice. BMS-754807 inhibits tumor growth in a selected group of epithelial (IGF-1R-Sal, GEO, and Colo205), hematopoietic (JJN3), and mesenchymal (RD1 and Rh41) xenograft tumor models with TGI ranging from 53% to 115%. BMS-754807 is effective at a dose level of 3.125 mg/kg twice daily and as low as 6.25 mg/kg once daily, in the highly sensitive Rh41 rhabdomyosarcoma. BMS-754807 (25 mg/kg) also shows synergy when combined with targeted agents in human tumor cell lines and human xenograft models^[1]. Furthmore, BMS-754807 is active at doses from 3 mg/kg upward in the IGF-Sal tumor model^[2]. BMS-754807 (25 mg/kg, p.o.) induces significant differences in EFS distribution compared to controls in 18 of 32 evaluable solid tumor xenografts (56%) tested, but in none of the ALL xenografts studied^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1001350-96-4
Appearance Solid
Masse moléculaire 461.49
Formule C₂₃H₂₄FN₉O
Color White to off-white
SMILES

FC1=CC=C(NC([C@@]2(C)N(C(N=C3NC4=NNC(C5CC5)=C4)=NN6C3=CC=C6)CCC2)=O)C=N1
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (14)

All Histological Imaging/StainingFlow CytometryOthersWBIF

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Journal Impact Factor

Sci Transl Med

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]

2018 Jul 18;10(450):eaaq1093. PMID: 30021885
Cancer Lett

High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-XL inhibition against Ewing sarcoma. [Abstract]

2023 Feb 1:554:216028. PMID: 36462556
Cell Rep

Insulin-like growth factor signaling regulates zebrafish lymphatic-vessel development. [Abstract]

2026 Feb 13;45(2):116971. PMID: 41691624

BMS-754807 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2026 Feb 13;45(2):116971. [Abstract]

Confocal images of the lateral head at 6 dpf comparing the cartilage and lymphatic phenotypes of lyve1b:dsRed (green) sox10:EGFP (magenta) larvae treated at 4 dpf with either DMSO (B), 0.61 μM (C), 1.25 μM (D), or 2.5 μM BMS-754807 (E).
JCI Insight

RAGE activation in macrophages and development of experimental diabetic polyneuropathy. [Abstract]

2022 Dec 8;7(23):e160555. PMID: 36477360

BMS-754807 purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Dec 8;7(23):e160555. [Abstract]

Motion maps of DRG neuron axons treated with a carrier and an insulin receptor antagonist (BMS-754807, 300 or 500 nmol/L). Stimulation time was 60 minutes.
mBio

Respiratory syncytial virus co-opts hypoxia-inducible factor-1α-mediated glycolysis to favor the production of infectious virus. [Abstract]

2023 Oct 31;14(5):e0211023. PMID: 37796013

BMS-754807 purchased from MedChemExpress. Usage Cited in: mBio. 2023 Oct 31;14(5):e0211023. [Abstract]

HEp-2 or HEK-293T cells were subjected to either simulated infection or RSV infection (MOI = 1) and cultured for a specified time with or without BMS-754807 (25 µM) or LY294002 (10 µM). Western blot analysis was performed on the expression of IR-α, IR-β, p-IRS1, IRS1, p-Akt, and Akt in HEp-2 cells at 0.25, 0.5, 1, 2, 6, 12, or 24 hours post-RSV infection.

BMS-754807 purchased from MedChemExpress. Usage Cited in: mBio. 2023 Oct 31;14(5):e0211023. [Abstract]

HEp-2 or HEK-293T cells were subjected to either simulated infection or RSV infection (MOI = 1) and cultured for a specified time with or without BMS-754807 (25 µM) or LY294002 (10 µM). Immunolocalization of EGFP-p85α and mCherry-IRS1 in HEK293T cells was performed at 2, 6, 12, or 24 hours post-RSV infection.
Sci Rep

Impact of prenatal Di(2-ethylhexyl) phthalate exposure on pubertal development in female offspring rats: A focus on ERα-Mediated IGF-1/NKB crosstalk in the hypothalamus. [Abstract]

2025 Jul 1;15(1):22255. PMID: 40595203
Cancers (Basel)

Regulation of IGF1R by MicroRNA-15b Contributes to the Anticancer Effects of Calorie Restriction in a Murine C3-TAg Model of Triple-Negative Breast Cancer. [Abstract]

2023 Aug 29;15(17):4320. PMID: 37686596
J Cell Mol Med

Inactivation of CDK12 Enhances Mitochondrial Efficiency to Suppress DNA Damage. [Abstract]

2026 Apr;30(7):e71101. PMID: 41896195
Oncol Rep

Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues. [Abstract]

2018 Aug;40(2):635-646. PMID: 29917168
J Cell Sci

Crucial role of TRPC6 in maintaining the stability of HIF-1α in glioma cells under hypoxia. [Abstract]

2015 Sep 1;128(17):3317-29. PMID: 26187851
Elife

Deciphering the preeclampsia-specific immune microenvironment and the role of pro-inflammatory macrophages at the maternal-fetal interface. [Abstract]

2025 Mar 28:13:RP100002. PMID: 40152904

BMS-754807 purchased from MedChemExpress. Usage Cited in: Elife. 2025 Mar 28:13:RP100002. [Abstract]

Frequencies of CD45RO+CCR7+Th17 cells. Black represents CD4+ naive T cells treated with DMSO; gray represents CD4+ naive T cells co-cultured with NP-EV-treated macrophages; blue represents CD4+ naive T cells co-cultured with PE-EV-treated macrophages; red represents CD4+ naive T cells treated with BMS-754807 (10 μM; 3 days) before co-cultured with PE-EV-treated macrophages.
biorxiv

2024 Jun 08.
University of North Carolina at Chapel Hill

2020 May.
Technical University of Munich

24.01.2018.

Solvant et solubilité

In Vitro:

DMSO : ≥ 100 mg/mL (216.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1669 mL

10.8345 mL

21.6689 mL

5 mM

0.4334 mL

2.1669 mL

4.3338 mL

10 mM

0.2167 mL

1.0834 mL

2.1669 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (5.42 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocole

Cell Assay^[1]

Cells are grown at their optimal density in RPMI+GlutaMax. Cell proliferation is evaluated by incorporation of 3H-thymidine into DNA after exposure of cells to BMS-754807 for 72 h. Results are expressed as an IC₅₀, which is the drug concentration required to inhibit cell proliferation by 50% compared with untreated control cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[1]

The required numbers of animals needed to detect a meaningful response are pooled at the start of the experiment and each is given a subcutaneous implant of a tumor fragment (appr 20 mg) with a 13-gauge trocar. Tumors are allowed to grow to the predetermined size window (75-200 mg; tumors outside the range are excluded), and animals are evenly distributed to various treatment and control groups. There are typically eight mice per treatment and control groups, with the exception of experiments conducted in the Sal-IGF (same as IGF-1R-Sal) tumor model, in which there are typically five mice per treatment and control group. Treatment of each animal is based on individual body weight. Treated animals are checked daily for treatment-related toxicity/mortality. Each group of animals is weighed before the initiation of treatment (Wt1) and then again following the last treatment dose (Wt2). The difference in body weight (Wt2 − Wt1) provides a measure of treatment-related toxicity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (286 KB)
SDS (393 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Carboni JM, et al. BMS-754807, a small molecule inhibitor of IGF-1R/IR. Mol Cancer Ther, 2009, 8(12), 3341-3349. [Content Brief]

[2]. Franks SE, et al. BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549. BMC Res Notes. 2016 Mar 1;9:134. [Content Brief]

[3]. Wittman MD, et al. Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of IGF-1R kinase in clinical development. J Med Chem, 2009, 52(23), 7360-7363. [Content Brief]

[4]. Kolb EA, et al. Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr Blood Cancer, 2011, 56(4), 595-603. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1669 mL	10.8345 mL	21.6689 mL	54.1724 mL
	5 mM	0.4334 mL	2.1669 mL	4.3338 mL	10.8345 mL
	10 mM	0.2167 mL	1.0834 mL	2.1669 mL	5.4172 mL
	15 mM	0.1445 mL	0.7223 mL	1.4446 mL	3.6115 mL
	20 mM	0.1083 mL	0.5417 mL	1.0834 mL	2.7086 mL
	25 mM	0.0867 mL	0.4334 mL	0.8668 mL	2.1669 mL
	30 mM	0.0722 mL	0.3611 mL	0.7223 mL	1.8057 mL
	40 mM	0.0542 mL	0.2709 mL	0.5417 mL	1.3543 mL
	50 mM	0.0433 mL	0.2167 mL	0.4334 mL	1.0834 mL
	60 mM	0.0361 mL	0.1806 mL	0.3611 mL	0.9029 mL
	80 mM	0.0271 mL	0.1354 mL	0.2709 mL	0.6772 mL
	100 mM	0.0217 mL	0.1083 mL	0.2167 mL	0.5417 mL

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Keywords

BMS-754807

14 Cited Publications

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BMS-754807

Linsitinib

Picropodophyllin

BMS-536924

NVP-AEW541

MK-2206 dihydrochloride

Insulin (human)

NVP-ADW742

GSK1904529A

PQ401

Ganitumab

Gemcitabine

Trametinib

Publications Citing Use of MedChemExpress (MCE) BMS-754807

Activité biologique

Chemical Information

Publications (14)

Solvant et solubilité

Protocole

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

BMS-754807

Linsitinib

Picropodophyllin

BMS-536924

NVP-AEW541

MK-2206 dihydrochloride

Insulin (human)

NVP-ADW742

GSK1904529A

PQ401

Ganitumab

Gemcitabine

Trametinib

Publications Citing Use of MedChemExpress (MCE) BMS-754807

Activité biologique

Chemical Information

Publications (14)

Solvant et solubilité

Protocole

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

BMS-754807 Related Classifications

HY-10200 Related Classifications

Bioz