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Daucosterol

(Synonyms: Eleutheroside A; β-Sitosterol β-D-glucoside)
7 Cited Publications
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Based on 7 publication(s) in Google Scholar

Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway.

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  • Pureté : 94.82%
  • CAS No.: 474-58-8
  • Formule: C35H60O6
  • Masse moléculaire:576.85
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Daucosterol Chemical Structure
    Daucosterol Chemical Structure
  • Experimental Validation Results for Daucosterol
  • Experimental Validation Results for Daucosterol
  • Experimental Validation Results for Daucosterol
  • Experimental Validation Results for Daucosterol
CAS No.: 474-58-8
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  • Daucosterol Chemical Structure
    Daucosterol Chemical Structure
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    Daucosterol purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2019 Jul 15:855:112-123. [Abstract]

    Customer Validation
     Western blot analysis of p53 expression and phosphorylation in DS treated A549 cells with the indicated concentrations after 72 h incubation. DS up-regulates p53 expression and phosphorylation which resulted in activation of downstream regulator p21.

  • 1/16

    Daucosterol purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2019 Jul 15:855:112-123. [Abstract]

    Customer Validation
     Anti-proliferative effect of Daucosterol (DS) (25, 50, 100, 200 μM) on malignant A549 cells by MTT assay.

  • 1/16

    Daucosterol purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2019 Jul 15:855:112-123. [Abstract]

    Customer Validation
     LDH leakage in Daucosterol (DS) (25, 50, 100, 200 μM) treated A549 cells with indicated concentrations after 72 h incubation.

  • 1/16

    Daucosterol purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2019 Jul 15:855:112-123. [Abstract]

    Customer Validation
     Propidium iodide staining and representative images of Daucosterol (DS) (100, 200 μM) treated A549 cells with indicated\ concentrations at 72 h incubation time. Cisplatin (10 μg/ml) was used as positive control against A549 cells. H202 (150 μM) was used as positive control against human PBMC cells. DMSO (0.02%) was kept as negative control to ensure their non-cytotoxic effects on A549 and L132 cells.

  • Daucosterol