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GW 4064

57 Cited Publications
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Based on 57 publication(s) in Google Scholar

GW 4064 is a potent FXR agonist with an EC50 of 65 nM.

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  • Pureté: 99.79%
  • CAS No.: 278779-30-9
  • Formule: C28H22Cl3NO4
  • Masse moléculaire:542.84
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • GW 4064 Chemical Structure
    GW 4064 Chemical Structure
  • Experimental Validation Results for GW 4064
  • Experimental Validation Results for GW 4064
  • Experimental Validation Results for GW 4064
  • Experimental Validation Results for GW 4064
  • Experimental Validation Results for GW 4064
CAS No.: 278779-30-9
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  • GW 4064 Chemical Structure
    GW 4064 Chemical Structure
    1/16
  • 1/16

    GW 4064 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2019 Dec 13;17(1):418. [Abstract]

    Customer Validation
     FXR suppresses gluconeogenesis and enhances glucose uptake in the HK-2 cell lines. The protein expression of FXR is obviously upregulates by GW4064 at 24, 48 and 72 h in the HK-2 cell lines.

  • 1/16

    GW 4064 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2019 Dec 13;17(1):418. [Abstract]

    Customer Validation
     FXR suppresses gluconeogenesis and enhances glucose uptake in the HK-2 cell lines. GW4064 at 4 μM inhibits the mRNA level of FXR.

  • 1/16

    GW 4064 purchased from MedChemExpress. Usage Cited in: FASEB J. 2019 Feb;33(2):2472-2483. [Abstract]

    Customer Validation
     FXRa protein expression in nontransduced (treated with DMSO or GW4064 for 9 d) and transduced shFXRa-dHepaRG cells, by Western blot analysis.

  • 1/16

    GW 4064 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2018 Jun 28;19(7). pii: E1898. [Abstract]

    Customer Validation
     Western blotting for p-FAK and total FAK. Cells are treated with vehicle control (Cont), 10 μM GW4064, or 32 μM GS in the absence or presence of 10 ng/mL TGF-β for 48 h. .

  • 1/16

    GW 4064 purchased from MedChemExpress. Usage Cited in: FEBS Lett. 2017 Sep;591(18):2836-2847. [Abstract]

    Customer Validation
     GW4064 inhibits NLRP3 inflammasome activation. The human PBMCs are primed with 500 ng/mL LPS for 3 h followed by GW4064 of indicated concentration(s) and different second signal stimulations, including Nigericin. The protein levels of activated caspase-1 and cleaved IL-1b are detected by western blot.

  • GW 4064