Salicylanilide
Based on 5 publication(s) in Google Scholar
Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.14%
- CAS No.: 87-17-2
- Formule: C13H11NO2
- Masse moléculaire:213.23
-
Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-15592
CabotegravirHIV Integrase Inhibitor -
HY-13305
MK-2048HIV-1/HTLV-1 Integrase Inhibitor -
HY-17392
ZalcitabineReverse Transcriptase Inhibitor -
HY-B1408R
Salicylanilide (Standard)HIV Inhibitor -
HY-14740
ElvitegravirHIV Integrase Inhibitor -
HY-10353
RaltegravirIntegrase Inhibitor -
HY-13238
Dolutegravir -
HY-15232
Tenofovir alafenamideReverse Transcriptase Inhibitor -
HY-17392R
Zalcitabine (Standard)Reverse Transcriptase Inhibitor -
HY-10574
RilpivirineNNRTI -
HY-B0249
DidanosineAnti-HIV Agent -
HY-90005
Etravirine
Publications Citing Use of MedChemExpress (MCE) Salicylanilide
More
Activité biologique
Description
IC50 & Target
|
HIV-1 |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>100 μM
Compound: 16
|
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay
|
[PMID: 30392371] |
| HepG2 | IC50 |
89.8 μM
Compound: SAL-5
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
|
[PMID: 24953953] |
In Vitro
Some Salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus is another virus, which can be potentially afflicted by Salicylanilides on the level of two enzymes-NS3 protease and NS5B RNA polymerase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 87-17-2
-
Appearance Solid
-
Masse moléculaire 213.23
-
Formule C13H11NO2
-
Color Light brown to brown
-
SMILES
O=C(NC1=CC=CC=C1)C2=CC=CC=C2O
-
Synonyms
2-Hydroxybenzanilide
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380 -
Int J Antimicrob Agents
2019 Dec;54(6):814-819. PMID: 31479744 -
-
-
Solvant et solubilité
In Vitro:
DMSO : 170 mg/mL (797.26 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureté et documentation
-
Fiche technique (284 KB)
-
SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6898 mL | 23.4489 mL | 46.8977 mL | 117.2443 mL |
| 5 mM | 0.9380 mL | 4.6898 mL | 9.3795 mL | 23.4489 mL | |
| 10 mM | 0.4690 mL | 2.3449 mL | 4.6898 mL | 11.7244 mL | |
| 15 mM | 0.3127 mL | 1.5633 mL | 3.1265 mL | 7.8163 mL | |
| 20 mM | 0.2345 mL | 1.1724 mL | 2.3449 mL | 5.8622 mL | |
| 25 mM | 0.1876 mL | 0.9380 mL | 1.8759 mL | 4.6898 mL | |
| 30 mM | 0.1563 mL | 0.7816 mL | 1.5633 mL | 3.9081 mL | |
| 40 mM | 0.1172 mL | 0.5862 mL | 1.1724 mL | 2.9311 mL | |
| 50 mM | 0.0938 mL | 0.4690 mL | 0.9380 mL | 2.3449 mL | |
| 60 mM | 0.0782 mL | 0.3908 mL | 0.7816 mL | 1.9541 mL | |
| 80 mM | 0.0586 mL | 0.2931 mL | 0.5862 mL | 1.4656 mL | |
| 100 mM | 0.0469 mL | 0.2345 mL | 0.4690 mL | 1.1724 mL |
Salicylanilide Related Classifications
HY-B1408 Related Classifications
Powered by Bioz