Tetracosactide
Based on 1 Customer Validation
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC50 of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.
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- Pureté: 99.46%
- CAS No.: 16960-16-0
- Formule: C136H210N40O31S
- Masse moléculaire:2933.44
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Stockage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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MC4R 0.65 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.65 nM
Compound: ACTH(1-24)
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Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
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[PMID: 24517312] |
Tetracosactide (11 nM, 3-60 h) promotes the protein synthesis in rats/mice adrenal slices, promotes the secretion of cortisol, 11-deoxycorticosterone, and aldosterone[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rabbits spinal cord IR injury models[2]
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Dosage:0.5 mg/kg
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Administration:iv, single dose
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Result:Reduced MDA, XO, MPO, caspase-3 in tissue and serum, inproved the levels of CAT.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 16960-16-0
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Appearance Solid
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Masse moléculaire 2933.44
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Formule C136H210N40O31S
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Color White to off-white
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Synonyms
Tetracosactrin; ACTH(1–24)
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Sequence
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
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Sequence Shortening
SYSMEHFRWGKPVGKKRRPVKVYP
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvant et solubilité
H2O : ≥ 200 mg/mL (68.18 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Instruction de manipulation (2659 KB)
Références
[2]. Kertmen H, et al., Comparative effects of methylprednisolone and tetracosactide (ACTH1-24) on ischemia/reperfusion injury of the rabbit spinal cord. Arch Med Sci. 2018 Oct;14(6):1459-1470. [Content Brief]
[3]. Haslach EM, et al., Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs). J Med Chem. 2014 Jun 12;57(11):4615-28. [Content Brief]
[4]. Lindhe O, et al., Irreversible binding and adrenocorticolytic activity of the DDT metabolite 3-methylsulfonyl-DDE examined in tissue-slice culture. Environ Health Perspect. 2001 Feb;109(2):105-10. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3409 mL | 1.7045 mL | 3.4090 mL | 8.5224 mL |
| 5 mM | 0.0682 mL | 0.3409 mL | 0.6818 mL | 1.7045 mL | |
| 10 mM | 0.0341 mL | 0.1704 mL | 0.3409 mL | 0.8522 mL | |
| 15 mM | 0.0227 mL | 0.1136 mL | 0.2273 mL | 0.5682 mL | |
| 20 mM | 0.0170 mL | 0.0852 mL | 0.1704 mL | 0.4261 mL | |
| 25 mM | 0.0136 mL | 0.0682 mL | 0.1364 mL | 0.3409 mL | |
| 30 mM | 0.0114 mL | 0.0568 mL | 0.1136 mL | 0.2841 mL | |
| 40 mM | 0.0085 mL | 0.0426 mL | 0.0852 mL | 0.2131 mL | |
| 50 mM | 0.0068 mL | 0.0341 mL | 0.0682 mL | 0.1704 mL | |
| 60 mM | 0.0057 mL | 0.0284 mL | 0.0568 mL | 0.1420 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tetracosactide Related Classifications
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