Acetoxycycloheximide
Acetoxycycloheximide is an antibiotic with antitumor activity. Acetoxycycloheximide a protein synthesis inhibitor. Acetoxycycloheximide significantly induces activation of procaspase-3 and subsequent apoptosis mediated by the Cytochrome c from mitochondria via activation of JNK pathway. Acetoxycycloheximide triggers the downregulation of cell surface TNF-R1 via the activation of ERK and p38 MAPK, thereby preventing activation of the NF-κB signaling pathway by TNF-α. Acetoxycycloheximide is much more toxic to female rats than to males. Acetoxycycloheximide can be used for inflammatory and immune diseases and cancers research.
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- CAS No.: 2885-39-4
- Formule: C17H25NO6
- Masse moléculaire:339.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Procaspase-3 |
NF-κB |
Chemical Information
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CAS No. 2885-39-4
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Masse moléculaire 339.38
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Formule C17H25NO6
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SMILES
O=C(N1)CC(CC1=O)C[C@@H](O)[C@H]2C([C@H](C[C@@](OC(C)=O)(C2)C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Kadohara K, et al. Acetoxycycloheximide (E-73) rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase. Biochem Pharmacol. 2005 Feb 15;69(4):551-60. [Content Brief]
[2]. PALLOTTA AJ, et al. Toxicology of acetoxycycloheximide as a function of sex and body weight. J Pharmacol Exp Ther. 1962 Jun;136:400-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Acetoxycycloheximide Related Classifications
HY-119420 Related Classifications
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