ALRT1550
ALRT1550 (LGD1550) is a selective retinoic acid receptor (RAR) agonist that binds RARs with exceptional potency, with Kd values of approximately 1-4 nM. ALRT1550 exhibits anti-proliferative activity, with an IC50 value of 0.22 nM in UMSCC-22B squamous carcinoma cells. In a mouse tumor xenograft model, ALRT1550 inhibited tumor growth in a dose-dependent manner, achieving a maximum inhibition rate of 89%. ALRT1550 is applicable for research in the field of cancer.
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- CAS No.: 178600-20-9
- Formule: C23H32O2
- Masse moléculaire:340.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CV-1 | EC50 |
134 nM
Compound: LG100567
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Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha
Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha
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[PMID: 8709094] |
| CV-1 | EC50 |
77 nM
Compound: LG100567
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Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma
Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma
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[PMID: 8709094] |
| CV-1 | EC50 |
87 nM
Compound: LG100567
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Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta
Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta
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[PMID: 8709094] |
| ME-180 | IC50 |
1 nM
Compound: 5; ALRT1550
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Antiproliferative activity against human ME-180 cells assessed as inhibition of cell growth by [3H]-thymidine incorporation based liquid scintillation counter analysis
Antiproliferative activity against human ME-180 cells assessed as inhibition of cell growth by [3H]-thymidine incorporation based liquid scintillation counter analysis
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[PMID: 33895500] |
Chemical Information
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CAS No. 178600-20-9
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Masse moléculaire 340.50
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Formule C23H32O2
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SMILES
OC(/C=C(C)/C=C/C=C(C1=CC(C(C)(C)C)=CC(C(C)(C)C)=C1)\C)=O
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Synonyms
LGD1550
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Shalinsky DR, et al. A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice. Cancer Res. 1997 Jan 1;57(1):162-8. [Content Brief]
[2]. Zhang L, et al. Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells. J Med Chem. 1996 Jul 5;39(14):2659-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALRT1550 Related Classifications
HY-106963 Related Classifications
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