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Cat. No.: HY-148269

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AN13762

AN13762 is a benzoxaborole antimalarial agent. AN13762 augments Plasmodium falciparum stress responses. AN13762 acts against cultured and fresh Plasmodium falciparum isolates and in vivo murine malaria models. AN13762 can be used for the research of malaria.

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CAS No.: 2025371-99-5
Formule: C₁₇H₁₈BN₃O₅
Masse moléculaire:355.15

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Please store the product under the recommended conditions in the Certificate of Analysis.

AN13762 Chemical Structure

CAS No.: 2025371-99-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Description

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In Vitro

AN13762 (1 nM-10 μM; 48 h) potently inhibits the growth of Plasmodium falciparum laboratory strains (3D7, W2, Dd2, 7G8, VS1, K1, D6) with IC₅₀ values ranging from 18 nM to 118 nM^[1].
AN13762 (72 h) potently inhibits the growth of fresh Plasmodium falciparum clinical isolates from Uganda^[1].
AN13762 (500 nM; 8 h) exhibits the greatest antimalarial activity against ring- and trophozoite-stage Plasmodium falciparum Dd2 parasites, causing abnormal trophozoite morphology and preventing further development^[1].
AN13762 produces low-level resistant Plasmodium falciparum (Dd2, 3D7, W2) with PfPARE mutations (IC₅₀ = 180-1340 nM) and high-level resistant parasites with additional ubiquitination/sumoylation or PfCPSF3 mutations (IC₅₀ = 1.1-5.0 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2025371-99-5
Masse moléculaire 355.15
Formule C₁₇H₁₈BN₃O₅
SMILES

O=C(N1CC(C)(C1)O)C2=CN=C(OC3=CC=C4C(B(OC4)O)=C3C)C=N2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Sindhe KMV, et al. Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation. mBio. 2020;11(1):e02640-19. Published 2020 Jan 28. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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AN13762

Voir tous les produits spécifiques à Isoform Parasite