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Cat. No.: HY-174157

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AR493

AR493 is an autophagy activator acting on AMPK (adenosine monophosphate-activated protein kinase). AR493 regulates pathways related to cellular energy sensing and increases autophagy levels. AR493 is promising for research of aging-associated diseases (such as diabetes, neurodegenerative diseases) and autophagy regulation.

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CAS No.: 1290546-06-3
Formule: C₁₆H₁₇N₃O₅
Masse moléculaire:331.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AR493 Chemical Structure

CAS No.: 1290546-06-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform AMPK :

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	CC₅₀	>100 μM Compound: 12d	Cytotoxicity against human HEL cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method Cytotoxicity against human HEL cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method	[PMID: 33894564]
HEp-2	CC₅₀	>100 μM Compound: 12d	Cytotoxicity in human Hep2 cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method Cytotoxicity in human Hep2 cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method	[PMID: 33894564]
MDCK	CC₅₀	>100 μM Compound: 12d	Cytotoxicity in dog MDCK cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method Cytotoxicity in dog MDCK cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method	[PMID: 33894564]
Vero	CC₅₀	>100 μM Compound: 12d	Cytotoxicity in African green monkey Vero cells assessed as reduction in cell viability measured after 5 days by resazurin dye based assay Cytotoxicity in African green monkey Vero cells assessed as reduction in cell viability measured after 5 days by resazurin dye based assay	[PMID: 33894564]

Chemical Information

CAS No. 1290546-06-3
Masse moléculaire 331.32
Formule C₁₆H₁₇N₃O₅
SMILES

CN(C1=CC=CC=C1OC2=CN3[C@H]4C[C@H](O)[C@@H](CO)O4)C2=NC3=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Guseva EA, et al. AMPK-specific autophagy activator based on 1,3-diaza-2-oxophenoxazine. Bioorg Chem. 2025 Jul 15;162:108588. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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AR493

Voir tous les produits spécifiques à Isoform AMPK