ATV041
ATV041 is an orally active Ibuprofen (HY-78131) and nucleotide analogue. ATV041 improves oral pharmacokinetic (PK) profile and tissue distribution with anti-mouse hepatitis virus (MHV) activity. ATV041 reduces viral load, tissue damage and virus-induced inflammation in a dose-dependent manner.
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- CAS No.: 2935937-67-8
- Formule: C25H29N5O5
- Masse moléculaire:479.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Mouse hepatitis virus (MHV)[1]
ATV041 inhibits CCoV, FIPV and TGEV with EC50 values of 1.406 μM, 7.34 μM and 3.777 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ATV041 (10, 50 and 200 mg/kg; p.o.; single dose) inhibits virus replication in liver and lung in a dose-dependent manner. ATV041 down-regulates the expression of TNF-α, IL-1β, IL-6, IFN-γand CXCL10 inflammatory factors and improves tissue damage[1].
Pharmacokinetic (PK) parameters of GS-441524 and Ibuprofen in SD rats[1]
(GS-441524 and Ibuprofen are produced by hydrolysis of ATV041)
| Analytes | Route | Dose (mg/kg) | T1/2 (h) | Tmax (h) | Cmax (μM/L) | AUC0-∞ (h μM/L) | MRT0-∞ (h) | F (%) |
| GS-441524 | p.o. | 25.0 | 4.98±3.57 | 0.67±0.29 | 7.75±1.58 | 22.6±2.34 | 3.16±1.21 | 60.31±0.06 |
| GS-441524 | i.v. | 5.0 | 2.81±3.28 | 0.08±0.00 | 5.67±0.57 | 7.51±0.85 | 1.28±0.139 | - |
| Ibuprofen | p.o. | 25.0 | 2.63±1.78 | 0.67±0.29 | 80.2±12 | 263±37 | 3.35±0.925 | 78.42±0.11 |
| Ibuprofen | i.v. | 5.0 | 1.58±0.82 | 0.03±0.00 | 41.8±3.12 | 67.1±4.39 | 1.57±0.294 | - |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rats[1].
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Dosage:5 or 25 mg/kg.
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Administration:Oral gavage or intravenous injection; single dose.
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Result:Showed an oral activity and efficacy.
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Animal Model:BALB/c mice[1].
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Dosage:10, 50 and 200 mg/kg.
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Administration:Oral gavage; single dose.
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Result:Improved tissue distribution and reduced viral load, tissue damage, virus-induced inflammation.
Chemical Information
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CAS No. 2935937-67-8
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Masse moléculaire 479.53
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Formule C25H29N5O5
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SMILES
O[C@H]1[C@@H](O)[C@](C#N)(C2=CC=C3C(N)=NC=NN32)O[C@@H]1COC(C(C)C(C=C4)=CC=C4CC(C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATV041 Related Classifications
HY-152535 Related Classifications
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