BJH-86
BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC50 = 5 μM). BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC50 >10 μM). BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer.
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- CAS No.: 3067849-10-6
- Formule: C23H21N3O2
- Masse moléculaire:371.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PDE10A |
BJH-86 (1-10 μM, 30 min-96 h) potently inhibits mitochondrial complex I (oxygen consumption rate inhibition IC50 = 5 μM) in A549 human lung cancer cells and EO771 murine breast cancer cells[1].
BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A, IC50 >10 μM) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl6 mice bearing EO771 xenografts[1]
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Dosage:2 mg/kg single dose 1 h before radiotherapy and 30 mg/kg repeated administration
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Administration:Intravenously injection
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Result:Reduced tumor hypoxia.
Enhanced radiosensitivity (5 Gy) .
Prolonged tumor growth delay from 2 days to 4 days.
Chemical Information
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CAS No. 3067849-10-6
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Masse moléculaire 371.43
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Formule C23H21N3O2
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SMILES
COC1=CC=C2N=CC=C(CC3=CC=CC(C4=CN(C5COC5)N=C4)=C3)C2=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BJH-86 Related Classifications
HY-178987 Related Classifications
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