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Cat. No.: HY-14132

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BMS-665053

BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC₅₀ = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC₅₀ = 4.9 nM).

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CAS No.: 1173435-64-7
Formule: C₁₆H₁₄Cl₃F₂N₃O₂
Masse moléculaire:424.66

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BMS-665053 Chemical Structure

CAS No.: 1173435-64-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Voir tous les produits spécifiques à Isoform CRFR :

CRFR1
CRFR2

Chemical Information

CAS No. 1173435-64-7
Masse moléculaire 424.66
Formule C₁₆H₁₄Cl₃F₂N₃O₂
SMILES

ClC1=CN([C@H](C2CC2)C)C(C(NC3=C(Cl)C=C(OC(F)F)C=C3Cl)=N1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jianqing Li, et al. An Efficient, Direct Bis-ortho-chlorination of 4-(Difluoromethoxy)aniline and Its Application to the Synthesis of BMS-665053, a Potent and Selective Pyrazinone-Containing Corticotropin-Releasing Factor-1 Receptor Antagonist. Organic Process Research & Development, 16, 156-159.

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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BMS-665053

Voir tous les produits spécifiques à Isoform CRFR

Activité biologique

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Chemical Information

Pureté et documentation

Références

Calculators

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HY-14132 Related Classifications

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