country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183960

Copy Link Print Information

BPyO-34

BPyO-34 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC₅₀ of 0.52 μM against human targets. BPyO-34 inhibits the activity of ASK1 in in vitro kinase assays. BPyO-34 can be used in research related to various diseases such as diabetes and cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 890601-68-0
Formule: C₃₂H₂₉FN₂O₅S
Masse moléculaire:572.65

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BPyO-34 Chemical Structure

CAS No.: 890601-68-0

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

BPyO-34 inhibits recombinant human ASK1 catalytic subunit with an IC₅₀ of 0.52 μM in an in vitro biochemical kinase assay^[1].
BPyO-34 (10 μM) shows preferential inhibition of recombinant human ASK1 over recombinant human CK2, FGFR1, Tie2, JNK3, and Aurora A^[1].
BPyO-34 binds to the ATP-binding pocket of human ASK1 via specific hydrogen bonding, hydrophobic, and sulfur-π interactions with key amino acid residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 890601-68-0
Masse moléculaire 572.65
Formule C₃₂H₂₉FN₂O₅S
SMILES

O=C(C1=C(C(N(C1C2=CC(OCCC(C)C)=CC=C2)C3=NC4=C(S3)C=C(F)C=C4)=O)O)C5=CC=C6OC(CC6=C5)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Starosyla SA, et al. Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one. Bioorg Med Chem. 2015;23(10):2489-2497. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis