CK-571
CK-571 is an allosteric inhibitor of smooth muscle myosin (Myosin)-2. CK-571 binds the SH1-relay cleft of the motor domain, traps the intermediate conformation of the recovery stroke and stabilizes the ATP-bound state, blocking ATP hydrolysis and F-actin (Actin) binding. CK-571 inhibits actin-activated ATPase activity of non-muscle, cardiac, and skeletal muscle myosin-2. CK-571 can be used in research related to asthma and chronic obstructive pulmonary disease (COPD).
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- CAS No.: 1119536-89-8
- Formule: C24H26ClFN4O5
- Masse moléculaire:504.94
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[4]|
Myosin-2 |
In Vitro
CK-571 (serially diluted in DMSO; final DMSO < 1%) inhibits smooth muscle myosin S1 actin-activated ATPase with an IC50 of 0.086 μM and shows lower potency against CMM, SKM, and NMM-2A[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1119536-89-8
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Masse moléculaire 504.94
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Formule C24H26ClFN4O5
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SMILES
O=C(OC[C@H](C[C@@H](O)CO)N(C)C(NCC1=C(Cl)C(F)=CC=C1)=O)NC2=NC=C3C(C=CC=C3)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CK-571 Related Classifications
HY-180792 Related Classifications
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