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Codrituzumab

(Synonyms: GC33; RO5137382)
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Codrituzumab (GC33) is a humanized monoclonal antibody targeting human GPC3 (glypican-3), with high affinity (Kd of 0.673 nM). GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC). Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth.

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  • Pureté: 99.07%
  • CAS No.: 1365267-33-9
  • Masse moléculaire:145.58 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Codrituzumab
  • Experimental Validation Results for Codrituzumab
  • Experimental Validation Results for Codrituzumab
  • Codrituzumab Chemical Structure
    Codrituzumab Chemical Structure
CAS No.: 1365267-33-9
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Glypican-3/GPC3 Protein, Human (HEK293, His, HY-P70487) can bind Codrituzumab. The EC50 for this effect is 13.3 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells with Codrituzumab (HY-P99013, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Codrituzumab Chemical Structure
    1/16
  • Codrituzumab
  • Immobilized Glypican-3/GPC3 Protein, Human (HEK293, His, HY-P70487) can bind Codrituzumab. The EC50 for this effect is 13.3 ng/mL.
  • Flow cytometric analysis of 1X106 Jurkat cells with Codrituzumab (HY-P99013, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).