GPC3 - glypican 3 Gene

Also Known as SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2719

About GPC3

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:133,535,745-133,985,594 (from NCBI)

This gene has 13 transcripts (splice variants), 205 orthologues, 5 paralogues and is associated with 72 phenotypes. Biased expression in placenta (RPKM 205.3), lung (RPKM 44.2) and 3 other tissues.

Summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the Dipeptidyl Peptidase activity of CD26, and it can induce Apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

GPC3 Products (4)

mRNA	Protein	Name
NM_001164617.2	NP_001158089.1	glypican-3 isoform 1 precursor
NM_001164618.2	NP_001158090.1	glypican-3 isoform 3 precursor
NM_001164619.2	NP_001158091.1	glypican-3 isoform 4 precursor
NM_004484.4	NP_004475.1	glypican-3 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables peptidyl-dipeptidase inhibitor activity	IDA IDA: Inferred from direct assay	17549790	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17549790	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	24496449	GOA
involved in regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	14610063	GOA
involved in regulation of non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	14610063	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPC3 Protein Structure

Glypican

0
100
200
300
400
500
580 a.a.

Protein Preferred Names	Protein Names
glypican-3	glypican proteoglycan 3

Recombinant GPC3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70367	Glypican-3/GPC3 Protein, Human (HEK293, Fc, solution)	P51654-1 (Q25-H559)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70487	Glypican-3/GPC3 Protein, Human (HEK293, His)	P51654-1 (Q25-H559)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72373	Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His-Avi)	P51654-1 (Q25-H559)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74122	Glypican-3/GPC3 Protein, Human (S495A, HEK293, Fc)	P51654-1/NP_004475.1 (Q25-S550, S495A)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77548	Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His)	P51654-1 (M1-H559)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78674	Glypican-3/GPC3 Protein, Human (S359F, HEK293, His)	P51654-1 (Q25-H559, S359F)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P70487G	GMP Glypican-3/GPC3 Protein, Human (HEK293, His)	P51654-1 (Q25-H559)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700414	Glypican-3/GPC3 Protein, Human (HEK293, His-Myc)	P51654-1 (Q25-H559, G537R)	≥ 90%, as determined by reducing SDS-PAGE.

GPC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82706	Glypican 3 Antibody (YA2451)	WB, FC	Human
HY-P84373	Glypican 3 Antibody (YA4070)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P84373A	Glypican 3 Antibody (YA4070)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P85917	Glypican 3 Antibody (YA5609)	IHC-P, WB, ICC/IF, ELISA	Human
HY-P85940	Glypican 3 Antibody (YA5632)	IHC-P, WB, ICC/IF, ELISA	Human
HY-P86050	Glypican 3 Antibody (YA5742)	IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Simpson-Golabi-Behmel Syndrome, Type 1	Simpson-Golabi-Behmel Syndrome Type 1 Simpson-Golabi-Behmel Syndrome SGBS1 Golabi-Rosen Syndrome Simpson Dysmorphia Syndrome Sgbs Bulldog Syndrome Dgsx Sdys Dysplasia Gigantism Syndrome, X-Linked X-Linked Dysplasia Gigantism Syndrome Dgsx Golabi-Rosen Syndrome Sara Angers Syndrome Sgb Syndrome Mental Retardation-Overgrowth Syndrome Simpson Dysplasia Syndrome Simpson Syndrome Simpson-Golabi-Behmel Syndrome 1 Dysplasia Gigantism Syndrome X-Linked
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Perlman Syndrome	Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor PRLMNS Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome Renal Hamartomas Nephroblastomatosis And Fetal Gigantism Nephroblastoma Fetal Macrosomia
Metaphyseal Undermodeling, Spondylar Dysplasia, And Overgrowth	Moreno-Nishimura-Schmidt Syndrome Mns Mns Syndrome Nishimura-Schmidt Syndrome Endochondral Gigantism Overgrowth-Metaphyseal Undermodeling-Spondylar Dysplasia Syndrome
Nipples, Supernumerary	Supernumerary Nipple Accessory Nipples Polymastia Polythelia, Familial Familial Supernumerary Nipples Isolated Polythelia Ectopic Nipple Extra Nipple Hyperthelia Polythelia
Hepatocellular Adenoma	Adenoma Hepatocellular
Proteus Syndrome	Proteus Syndrome, Somatic Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly Wiedemann'S Syndrome Hemihypertrophy And Macrocephaly Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly Ps PROTEUSS Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly
Omphalocele	Omphalocoele Congenital Omphalocele Exomphalos Exumbilication
Hepatoblastoma
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Ovarian Endodermal Sinus Tumor	Endodermal Sinus Tumor Of Ovary Ovarian Yolk Sac Tumor Endodermal Sinus Tumour Of Ovary Ovarian Endodermal Sinus Tumour Ovarian Yolk Sac Tumour
Sotos Syndrome	Cerebral Gigantism SOTOS Chromosome 5q35 Deletion Syndrome Sotos Syndrome 1, Formerly Sotos1, Formerly Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development Sotos Sequence Sotos' Syndrome Sotos1 Sotos Syndrome 1
Choriocarcinoma	Chorioepithelioma
Hepatoid Adenocarcinoma
Ovarian Primitive Germ Cell Tumor
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Benign Mesothelioma	Mesothelioma Benign Tumor Of Mesothelium Adenomatoid Tumor
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits
Double Outlet Right Ventricle	Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect Taussig-Bing Syndrome Dextrotransposition Of Aorta Taussig-Bing Syndrome Or Defect Dorv Dorv With Subpulmonary Vsd Dorv-Tga Double Outlet Right Ventricle With Transposition Of The Great Arteries Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type Taussig-Bing Heart Taussig-Bing Malformation Taussig-Bing Complex Taussig-Bing Defect Taussig-Bing Double Outlet Right Ventricle With Remote Ventricular Septal Defect Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect Double Outlet Right Ventricle With Non-Committed Interventricular Communication Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Mixed Germ Cell Cancer	Mixed Germ Cell Tumor Mixed Germ Cell Neoplasm Mixed Germ Cell Tumour Mixed Teratoma And Seminoma
Merkel Cell Carcinoma	Trabecular Adenocarcinoma Cutaneous Neuroendocrine Carcinoma Trabecular Carcinoma Carcinoma, Merkel Cell Merkel Cell Cancer Merkle Tumors Mcc Carcinoma Merkel Cell
Acromegaly	Gigantism Growth Hormone Excess Pituitary Giant Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma
Omodysplasia	Omodysplasia Type 1 Omodysplasia 2
Testicular Yolk Sac Tumor	Testicular Yolk Sac Neoplasm Endodermal-Sinus Tumor Orchidoblastoma Yolk Sac Tumor
Liver Benign Neoplasm	Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Bile Duct Cancer	Bile Duct Carcinoma Extrahepatic Bile Duct Carcinoma Carcinoma Of Extrahepatic Bile Duct Extrahepatic Bile Duct Cancer Bile Duct Neoplasms Bile Duct Tumor Ca Extrahepatic Bile Ducts Malignant Neoplasm Of The Extrahepatic Bile Duct Bile Duct Extrahepatic Carcinoma Malignant Tumor Of Extrahepatic Bile Duct
Sublingual Gland Adenoid Cystic Carcinoma
Ovarian Germ Cell Cancer	Ovarian Germ Cell Tumor Malignant Germ Cell Tumor Of Ovary Germ Cell Neoplasm Of Ovary Germ Cell Tumor Of Ovary Mogct Malignant Ovarian Germ Cell Tumor Malignant Ovarian Germ Cell Neoplasm
Sublingual Gland Cancer	Malignant Tumor Of Sublingual Gland Malignant Tumor Of The Sublingual Gland
Testicular Malignant Germ Cell Cancer	Malignant Germ Cell Tumor Of Testis
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Mixed Hepatoblastoma	Mixed Epithelial And Mesenchymal Hepatoblastoma
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Endodermal Sinus Tumor	Yolk Sac Tumor Endodermal Sinus Tumour Hepatoid Yolk Sac Tumour Infantile Embryonal Carcinoma Yolk Sac Neoplasm Yolk Sac Tumour
Sarcomatous Intrahepatic Cholangiocarcinoma	Sarcomatoid Intrahepatic Cholangiocarcinoma
Wilms Tumor 5	Wilms Tumor WT5 Wilms Tumor Susceptibility-5 Wilms Tumor And Radial Bilateral Aplasia Nephroblastoma Wilms' Tumor Wilms Tumor, Susceptibility To Wtsl Bilateral Radial Aplasia With Wilms Tumor Embryonal Adenosarcoma Embryonal Nephroma Kidney Wilms Tumor Kidney, Adenomyosarcoma, Embryonal Kidney, Carcinosarcoma, Embryonal Kidney, Embryoma Kidney, Embryonal Mixed Tumor Nephroma Renal Adenosarcoma Renal Cancer, Wilms Renal Wilms Tumor Tumor, Wilms Hereditary Susceptibility To Wilms Tumor 5
Sclerosing Hepatic Carcinoma	Sclerosing Hepatocellular Carcinoma
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Malignant Teratoma	Immature Teratoma Malignant Extragonadal Teratoma Primary Malignant Extragonadal Teratoma Teratoma, Malignant, Nos Teratoma, Malignant Immature Extragonadal Teratoma
Ovarian Embryonal Carcinoma	Embryonal Carcinoma Of Ovary Embryonal Carcinoma Of The Ovary
Mature Teratoma	Dermoid Cyst Benign Teratoma
Ovarian Clear Cell Carcinoma	Clear-Cell Ovarian Carcinoma
Adult Hepatocellular Carcinoma	Adult Primary Hepatocellular Carcinoma Adult Hepatoma Adult Hcc
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Intrahepatic Cholangiocarcinoma	Cholangiocarcinoma Intrahepatic Bile Duct Carcinoma Peripheral Cholangiocarcinoma Peripheral Intrahepatic Cholangiocarcinoma Adenocarcinoma Of Intra-Hepatic Bile Ducts Cholangiocarcinoma, Unspecified Site Cholangiocarcinoma Of Liver
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Ovarian Gonadoblastoma
Rhabdomyosarcoma
Sotos Syndrome 1	Sotos1 Sotos Syndrome, Type 1 Sotos' Syndrome
Germ Cell Cancer	Malignant Germ Cell Tumor Neoplasms, Germ Cell And Embryonal Germ Cell Neoplasm Germ Cell Tumour Malignant Tumor Of The Germ Cell Neoplasms Germ Cell Malignant Germ Cell Neoplasm
Large Congenital Melanocytic Nevus	Giant Pigmented Hairy Nevus Giant Congenital Melanocytic Nevus Gmn Congenital Pigmented Nevus Lcmn Gphn Giant Congenital Nevus Bathing Trunk Nevus Congenital Giant Pigmented Nevus Congenital Hairy Nevus Giant Hairy Nevus Giant Pigmented Nevus Congenital Giant Pigmented Nevus Of Skin Congenital Melanocytic Nevus Syndrome Giant Congenital Melanocytic Nevi Giant Congenital Pigmented Nevus Melanocytic Nevus Syndrome, Congenital
Weaver Syndrome	Wss Weaver-Smith Syndrome WVS Weaver-Like Syndrome Weaver-Williams Syndrome Camptodactyly-Overgrowth-Unusual Facies Syndrome Camptodactyly - Overgrowth - Unusual Facies Ezh2 Related Overgrowth Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly Weaver Smith Syndrome Weaver Like Syndrome Weaver Williams Syndrome Camptodactyly-Overgrowth-Unusual Facies Weaver Syndrome 1 Weaver Syndrome 2 Wvs1 Wvs2
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor
Diaphragmatic Hernia, Congenital	Congenital Diaphragmatic Hernia Diaphragmatic Hernia Cdh Congenital Diaphragmatic Defect Hernia, Diaphragmatic Dih Hernia, Congenital Diaphragmatic Hcd Diaphragmatic Defect, Congenital Diaphragm, Unilateral Agenesis Of Hemidiaphragm, Agenesis Of Diaphragmatic Hernia 1 Agenesis Of Hemidiaphragm Unilateral Agenesis Of Diaphragm Hernia Diaphragmatic Hernia Diaphragmatic Congenital Hernia, Diaphragmatic, Type 1 Hiatus Hernia Oesophageal Hiatus Hernia Paraoesophageal Hernia Sliding Hiatus Hernia Congenital Diaphragm Hernia Congenital Diaphragm Defect With Hernia Gross Congenital Diaphragm Defect
Liver Leiomyosarcoma	Leiomyosarcoma Of The Liver

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99013	Codrituzumab	Inhibitor	99.07%	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153360	MC-GGFG-AM-(10Me-11F-Camptothecin)	Inhibitor	98.99%	Unkown
HY-P10888A	GPC3 targeting peptide 1 TFA		99.40%	Unkown
HY-W1124925	DOTA-GPC3 targeting peptide 2	Ligand	98.83%	Unkown
HY-182099	DSPE-PEG1000-DHLASLWWGTEL		/	Unkown
HY-182099A	DSPE-PEG2000-DHLASLWWGTEL		/	Unkown
HY-182099B	DSPE-PEG3400-DHLASLWWGTEL		/	Unkown
HY-182099C	DSPE-PEG5000-DHLASLWWGTEL		/	Unkown
HY-185742	ZW-251	Inhibitor	/	Unkown
HY-P11618	10P3Me	Ligand	/	Unkown
HY-RS05628	GPC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10888	GPC3 targeting peptide 1		/	Unkown
HY-RS16630	Gpc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23065	Gpc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990840	Anti-GPC3 Antibody (YP7)	Inhibitor	≥95.0%	Unkown
HY-P990841	Anti-pan-Glypican Antibody (HS20)	Inhibitor	99.44%	Unkown
HY-P992011	CAT-07	Inhibitor	/	Unkown
HY-P992457	SAR444200	Activator	/	Unkown
HY-P992514	ZW-251 Antibody	Inhibitor	/	Unkown
HY-P991448	MDX-1414	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPC3	VGNC	VGNC:67405
Bos taurus	GPC3	VGNC	VGNC:29525
Mus musculus	GPC3	MGD	MGI:104903
Canis familiaris	GPC3	VGNC	VGNC:41373
Macaca mulatta	GPC3	VGNC	VGNC:73117
Rattus norvegicus	GPC3	RGD	RGD:2725
Others	GPC3	NCBI