2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Topoisomerase
  4. ZW-251

ZW-251 is a glypican-3 (GPC3)-targeted antibody-drug conjugate (ADC) with topoisomerase-I inhibitory activity. ZW-251 induces cytotoxicity, penetrates tumor spheroids, exerts bystander cytotoxicity, and inhibits tumor growth in hepatocellular carcinoma models. ZW-251 can be used for the research of hepatocellular carcinoma.

For research use only. We do not sell to patients.

ZW-251

ZW-251 Chemical Structure

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ZW-251 Related Antibodies

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Description

ZW-251 is a glypican-3 (GPC3)-targeted antibody-drug conjugate (ADC) with topoisomerase-I inhibitory activity. ZW-251 induces cytotoxicity, penetrates tumor spheroids, exerts bystander cytotoxicity, and inhibits tumor growth in hepatocellular carcinoma models. ZW-251 can be used for the research of hepatocellular carcinoma[1][2].

IC50 & Target[1]

Topoisomerase I

 

In Vitro

ZW-251 (0.001-100 nM; 4 days) exhibits cell cytotoxicity to HepG2 spheroid liver cancer cell line[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZW-251 Related Antibodies
Parmacokinetics
Species Dose Route T1/2
Cynomolgus Monkey[2] 20 mg/kg i.v. 110.4 h
Cynomolgus Monkey[2] 60 mg/kg i.v. 115.2 h
Cynomolgus Monkey[2] 120 mg/kg i.v. 129.6 h
In Vivo

ZW-251 (20-120 mg/kg; i.v.; 3 doses at day 1, 22 and 43) is well tolerated in cynomolgus monkeys and exhibits dose-proportional PK[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys
[2]
Dosage: 20 mg/kg; 60 mg/kg; 120 mg/kg
Administration: i.v.; 3 doses at day 1, 22 and 43
Result: Was well tolerated in cynomolgus monkeys.
Exhibited dose-proportional PK.
SMILES

[ZW-251]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZW-251 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZW-251ZW251ZW 251Antibody-Drug Conjugates (ADCs)TopoisomeraseAntibody-Drug Conjugatescamptothecin derivativeGPC3tumor cellsglypican-3non-human primatestumor spheroidstopoisomerase-Ihepatocellular carcinomaInhibitorinhibitorinhibit

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