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Cat. No.: HY-153154

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COMC-6

(Synonyms: 2-Crotonyloxymethyl-2-cyclohexenone)

COMC-6 is an anticancer agent and can be used for study of cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 106281-45-2
Formule: C₁₁H₁₄O₃
Masse moléculaire:194.23

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

COMC-6 Chemical Structure

CAS No.: 106281-45-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

COMC-6 is an anticancer agent and can be used for study of cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	55 μM Compound: 2, COMC	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 17174551]
A549	IC₅₀	55 μM Compound: 2, COMC	Cytotoxicity against human A549 cells assessed as surviving cells after 4 days by MTT assay Cytotoxicity against human A549 cells assessed as surviving cells after 4 days by MTT assay	[PMID: 17870533]
B16	IC₅₀	0.046 μM Compound: COMC-6	Tested in vitro growth inhibition against B16 melanotic melanoma cells Tested in vitro growth inhibition against B16 melanotic melanoma cells	[PMID: 12502374]
HepG2	IC₅₀	5.93 μM Compound: COMC-6	Antiproliferative activity against human HepG2 cells by MTT assay Antiproliferative activity against human HepG2 cells by MTT assay	[PMID: 32787089]
HT-29	IC₅₀	0.8 μM Compound: COMC-6	Tested for cytotoxicity against HT-29 (wt)cells Tested for cytotoxicity against HT-29 (wt)cells	[PMID: 12502374]
HT-29	IC₅₀	1.8 μM Compound: COMC-6	Tested for cytotoxicity against HT-29 (MDR)cells Tested for cytotoxicity against HT-29 (MDR)cells	[PMID: 12502374]
HT-29	IC₅₀	4.37 μM Compound: COMC-6	Antiproliferative activity against human HT-29 cells by MTT assay Antiproliferative activity against human HT-29 cells by MTT assay	[PMID: 32787089]
NCI-H460	IC₅₀	40 μM Compound: 2, COMC	Cytotoxicity against human H460 cells by MTT assay Cytotoxicity against human H460 cells by MTT assay	[PMID: 17174551]
NCI-H460	IC₅₀	40 μM Compound: 2, COMC	Cytotoxicity against human H460 cells assessed as surviving cells after 4 days by MTT assay Cytotoxicity against human H460 cells assessed as surviving cells after 4 days by MTT assay	[PMID: 17870533]

In Vitro

COMC-6 (72 h) inhibits the proliferation of B16 murine melanoma cells with the IC₅₀ of 0.041 µM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 106281-45-2
Masse moléculaire 194.23
Formule C₁₁H₁₄O₃
SMILES

C/C=C/C(OCC1=CCCCC1=O)=O
Synonyms

2-Crotonyloxymethyl-2-cyclohexenone
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Joseph E, et al. Molecular basis of the antitumor activities of 2-crotonyloxymethyl-2-cycloalkenones. J Med Chem. 2003;46(1):194-196. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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