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Cat. No.: HY-151802

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CPUL1

CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective.

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CAS No.: 2043660-80-4
Formule: C₂₂H₁₃Cl₂N₅O
Masse moléculaire:434.28

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

CPUL1 Chemical Structure

CAS No.: 2043660-80-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform TrxR :

TrxR1
TrxR2

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.8 μM Compound: 1i	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 27836197]
HCT-116	IC₅₀	8 μM Compound: 1i	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 27836197]
HepG2	IC₅₀	2.1 μM Compound: 1i	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 27836197]
MCF7	IC₅₀	7.3 μM Compound: 1i	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 27836197]

In Vitro

CPUL1 (2.5, 5, 10, 20, 40 μM; 48 h) inhibits A549 cell proliferation and (2, 4, 8 μM; 48 h) colony formation^[1].
CPUL1 (4, 8 μM; 0, 24, 48 h) inhibits A549 cells migration and (2, 4, 8 μM; 48 h) invasion^[1].
CPUL1 hinders EMT (epithelial-mesenchymal transition) progress and affects MAPK pathway in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A549 cells
Concentration:

2.5, 5, 10, 20, 40 μM
Incubation Time:

48 h
Result:

Showed a dose-dependent cytotoxicity, with an IC₅₀ value of 7.61 μM.

Cell Viability Assay^[1]

Cell Line:

A549 cells
Concentration:

2, 4, 8 μM
Incubation Time:

48 h
Result:

Significantly abolished the capacity of A5459 cells to form colonies at the dose-dependent concentration.

Cell Migration Assay ^[1]

Cell Line:

A549 cells
Concentration:

4, 8 μM
Incubation Time:

0, 24, 48 h
Result:

Inhibited the migration of A549 cells in a dose- and time-dependent manner.

Chemical Information

CAS No. 2043660-80-4
Masse moléculaire 434.28
Formule C₂₂H₁₃Cl₂N₅O
SMILES

N#CC1=C(OC2=C(C1C3=CC(Cl)=C(Cl)C=C3)C4=NC5=CC=CC=C5N=C4C=C2N)N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ding Q, et al. A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production. Mol Biol Rep. 2022 Sep;49(9):8835-8845. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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CPUL1

Voir tous les produits spécifiques à Isoform TrxR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CPUL1 Related Classifications

HY-151802 Related Classifications