Cat. No.: HY-P3291

Dapiglutide

(Synonyms: ZP7570)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects.

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Pureté: 98.52%
CAS No.: 2296814-85-0
Formule: C₁₉₂H₃₀₂N₄₆O₅₇
Masse moléculaire:4166.79

Stockage:

Sealed storage, away from moisture and light, under nitrogen.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Dapiglutide Chemical Structure

CAS No.: 2296814-85-0

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Activité biologique
- Description
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Dapiglutide has an EC₅₀ of 190 pM for GLP-1R and an EC₅₀ of 210 pM for GLP-2R in HEK293 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dapiglutide (6-250 nmol/kg, subcutaneous injection, once daily for three days) effectively alleviates intestinal dysfunction in mice^[2].
Dapiglutide (100 nmol/kg, once daily for four weeks) can reduce body weight in obese mice^[3].
Pharmacokinetic Analysis in MC38 Syngeneic Model^[2]

Route	Dose (nmol/kg)	Animal	T_1/2 (h)	T_max (h)	F (%)
s.c.	10	Mice	3.6	4.5	71
s.c.	10	Rats	7.7	9.0	58

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A murine SB model of intestinal insufficiency with 40% ileocecal resection^[2]
Dosage:

6 and 250 nmol/kg; daily; 3 days
Administration:

Subcutaneous injection (s.c.)
Result:

Improved oral glucose tolerance, shortened intestinal transit time, promoted intestinal growth, significantly increased villus height and intestinal length, and reduced fecal water loss.

Animal Model:

DIO rats^[3]
Dosage:

100 nmol/kg; daily; 4 weeks
Administration:
Result:

Reduced weight and was more effective when combined with ZP8396.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2296814-85-0
Appearance Solid
Masse moléculaire 4166.79
Formule C₁₉₂H₃₀₂N₄₆O₅₇
Color White to off-white
Synonyms

ZP7570
Sequence

His-{Aib}-Glu-Gly-Ser-Phe-Thr-Ser-Glu-Leu-Ala-Thr-Ile-Leu-Asp-Lys(γGlu-octadecanedioic acid)-Gln-Ala-Ala-Arg-Asp-Phe-Ile-Ala-Trp-Leu-Ile-Gln-His-Lys-Ile-Thr-Asp
Sequence Shortening

H-{Aib}-EGSFTSELATILD-Lys(γGlu-octadecanedioic acid)-QAARDFIAWLIQHKITD
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Publications (1)

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Cardiovasc Diabetol

Excessive accumulation of epicardial adipose tissue promotes microvascular obstruction formation after myocardial ischemia/reperfusion through modulating macrophages polarization. [Abstract]

2024 Jul 5;23(1):236. PMID: 38970123

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (12.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.2400 mL

1.2000 mL

2.3999 mL

5 mM

0.0480 mL

0.2400 mL

0.4800 mL

10 mM

0.0240 mL

0.1200 mL

0.2400 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (0.60 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact

MedChemExpress (MCE) .

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zealand Pharma doses first subject in Phase 1 clinical trial with potential next generation dual-acting peptide therapeutic for short bowel syndrome. 26 June 2019.

[2]. Johannes Reiner, et al. Dapiglutide, a novel dual GLP-1 and GLP-2 receptor agonist, attenuates intestinal insufficiency in a murine model of short bowel. JPEN J Parenter Enteral Nutr. 2022 Jul;46(5):1107-1118. [Content Brief]

[3]. Copenhagen, et al. Anti-obesity Effect of Dapiglutide Alone and in Combination With the Amylin Analog ZP8396 in DIO Rat. obesity. Spring Vol. 30, (Nov 2022): 11-12.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.2400 mL	1.2000 mL	2.3999 mL	5.9998 mL
	5 mM	0.0480 mL	0.2400 mL	0.4800 mL	1.2000 mL
	10 mM	0.0240 mL	0.1200 mL	0.2400 mL	0.6000 mL

Keywords

Dapiglutide

1 Cited Publications

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Dapiglutide

Peptide Library

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Clinical Compound Library Plus

Publications Citing Use of MedChemExpress (MCE) Dapiglutide

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Dapiglutide

Peptide Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Publications Citing Use of MedChemExpress (MCE) Dapiglutide

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Dapiglutide Related Classifications

HY-P3291 Related Classifications